Deshpande U R, Nadkarni G D
Radiation Medicine Centre, B.A.R.C., Bombay, India.
Thyroidology. 1992 Dec;4(3):93-7.
Rats were made hypo and 'hyperthyroid' with propylthiouracil (PTU) and L-Thyroxine (L-T) respectively. The hypo and hyperthyroid status in these rats were confirmed by serum level of T4 and T3. Liver iron was significantly increased in both the hypo and hyperthyroid animals. However, liver ferritin synthesis rate was reduced by 36% in hypothyroid rats, and elevated by 38% in hyperthyroid ones. A similar trend was seen in liver ferritin concentration. Further, serum transaminases were elevated only in animals of the hyperthyroid group. It appears from the present data that ferritin metabolism is influenced by thyroid hormone as well as by iron. Thus, the raised serum ferritin in hyperthyroid patients may be partially attributed to increased ferritin synthesis in the liver and its possible leakage into circulation.
分别用丙硫氧嘧啶（PTU）和左旋甲状腺素（L-T）使大鼠甲状腺功能减退和亢进。通过血清T4和T3水平证实了这些大鼠的甲状腺功能减退和亢进状态。甲状腺功能减退和亢进的动物肝脏铁含量均显著增加。然而，甲状腺功能减退的大鼠肝脏铁蛋白合成率降低了36%，而甲状腺功能亢进的大鼠则升高了38%。肝脏铁蛋白浓度也呈现类似趋势。此外，仅甲状腺功能亢进组动物的血清转氨酶升高。从目前的数据来看，铁蛋白代谢受甲状腺激素以及铁的影响。因此，甲状腺功能亢进患者血清铁蛋白升高可能部分归因于肝脏中铁蛋白合成增加及其可能渗漏入循环系统。
