一项回顾性观察研究，旨在评估有或无既往输血史患者的输血不良反应。

A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history.

作者信息

Kato H, Nakayama T, Uruma M, Okuyama Y, Handa M, Tomiyama Y, Shimodaira S, Takamoto S

机构信息

Department of Transfusion Medicine, Aichi Medical University, Nagakute, Japan.

出版信息

Vox Sang. 2015 Apr;108(3):243-50. doi: 10.1111/vox.12208. Epub 2014 Dec 23.

DOI:10.1111/vox.12208

PMID:25536173

Abstract

BACKGROUND AND OBJECTIVES

This study compares the frequency of adverse transfusion reactions (ATRs) after first transfusions with the frequency of ATRs for subsequent (non-first) transfusions.

MATERIALS AND METHODS

Five hospitals agreed to systematically collect and share 2 years of data. This was a retrospective observational analysis of data including the number of transfusion episodes and ATRs for red blood cells (RBCs), fresh frozen plasma (FFP) and platelet concentrates (PCs) given to first-time transfusion recipients and to those previously transfused.

RESULTS

First transfusion ATRs to RBCs, FFP and PCs were 1.08%, 2.84% and 3.34%, respectively. These are higher than ATR incidences to RBCs (0.69%), FFP (1.91%) and PCs (2.75%) on subsequent transfusions. Specifically, first transfusion incidences of febrile non-haemolytic transfusion reactions (FNHTRs) to RBCs (0.43%) and allergic reactions to FFP (2.51%) were higher than on subsequent transfusions (RBCs: 0.23%, FFP: 1.65%).

CONCLUSION

There are risks of ATRs on the first transfusion as well as transfusions of patients with transfusion history.

摘要

背景与目的

本研究比较首次输血后不良输血反应（ATR）的发生频率与后续（非首次）输血时ATR的发生频率。

材料与方法

五家医院同意系统收集并共享两年的数据。这是一项对数据的回顾性观察分析，数据包括首次输血受者和既往输血者接受红细胞（RBC）、新鲜冰冻血浆（FFP）和血小板浓缩物（PC）的输血次数及ATR情况。

结果

首次输血时RBC、FFP和PC的ATR发生率分别为1.08%、2.84%和3.34%。这些高于后续输血时RBC（0.69%）、FFP（1.91%）和PC（2.75%）的ATR发生率。具体而言，首次输血时RBC发热性非溶血性输血反应（FNHTR）的发生率（0.43%）和FFP过敏反应的发生率（2.51%）高于后续输血（RBC：0.23%，FFP：1.65%）。