Department of Imaging, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite, F-69495, France.
Department of Urinary and Vascular Radiology, Hospices Civils de Lyon, Hôpital Edouard Herriot, 5 place d'Arsonval, 69437 Lyon Cedex 03, France; Université de Lyon, Université Lyon 1, Faculté de Médcine Lyon Est, 69003 Lyon, France.
Nat Rev Nephrol. 2015 May;11(5):288-301. doi: 10.1038/nrneph.2014.231. Epub 2014 Dec 23.
Owing to improvements in catheters and embolic agents, renal artery embolization (RAE) is increasingly used to treat nephrological and urological disease. RAE has become a useful adjunct to medical resuscitation in severe penetrating, iatrogenic or blunt renal traumatisms with active bleeding, and might avoid surgical intervention, particularly among patients that are haemodynamically stable. The role of RAE in pre-operative or palliative management of advanced malignant renal tumours remains debated; however, RAE is recommended as a first-line therapy for bleeding angiomyolipomas and can be used as a preventative treatment for angiomyolipomas at risk of bleeding. RAE represents an alternative to nephrectomy in various medical conditions, including severe uncontrolled hypertension among patients with end-stage renal disease, renal graft intolerance syndrome or autosomal dominant polycystic kidney disease. RAE is increasingly used to treat renal artery aneurysms or symptomatic renal arteriovenous malformations, with a low complication rate as compared with surgical alternatives. This Review highlights the potential use of RAE as an adjunct in the management of renal disease. We first compare and contrast the technical approaches of RAE associated with the various available embolization agents and then discuss the complications associated with RAE and alternative procedures.
由于导管和栓塞剂的改进,肾动脉栓塞术(RAE)越来越多地用于治疗肾脏和泌尿科疾病。RAE 已成为严重穿透性、医源性或钝性肾创伤伴活动性出血的重要辅助治疗方法,可避免手术干预,尤其是在血流动力学稳定的患者中。RAE 在晚期恶性肾肿瘤的术前或姑息治疗中的作用仍存在争议;然而,RAE 被推荐作为出血性血管平滑肌脂肪瘤的一线治疗方法,也可用于有出血风险的血管平滑肌脂肪瘤的预防性治疗。RAE 在各种医学情况下代表了一种替代肾切除术的方法,包括终末期肾病患者的严重无法控制的高血压、肾移植不耐受综合征或常染色体显性多囊肾病。RAE 越来越多地用于治疗肾动脉动脉瘤或有症状的肾动静脉畸形,与手术替代方法相比,并发症发生率较低。本综述强调了 RAE 在肾脏疾病治疗中的潜在应用。我们首先比较和对比了与各种可用栓塞剂相关的 RAE 的技术方法,然后讨论了 RAE 相关的并发症和替代治疗方法。