Nord C E, Lindmark A, Persson I
Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
J Antimicrob Chemother. 1989 Sep;24 Suppl A:113-7. doi: 10.1093/jac/24.suppl_a.113.
The activity of meropenem was determined against 350 strains of anaerobic bacteria by an agar dilution method. It was compared with those of piperacillin, cefoxitin, imipenem, clindamycin, metronidazole and chloramphenicol. Meropenem and imipenem were the most active agents tested. On the basis of these results, meropenem appears to be a promising antimicrobial agent for anaerobic infections and warrants further clinical investigation.
采用琼脂稀释法测定了美罗培南对350株厌氧菌的活性。并将其与哌拉西林、头孢西丁、亚胺培南、克林霉素、甲硝唑和氯霉素进行了比较。美罗培南和亚胺培南是测试的活性最强的药物。基于这些结果，美罗培南似乎是一种有前景的用于厌氧菌感染的抗菌药物，值得进一步进行临床研究。
