GNB3基因C825T多态性与癌症风险关联的定量评估。

Quantitative assessment of the association between GNB3 C825T polymorphism and cancer risk.

作者信息

Wang Yong, Zhang Shulong

机构信息

Department of Interventional Radiology & Vascular Surgery, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.

出版信息

J BUON. 2014 Oct-Dec;19(4):1092-5.

PMID:25536621

Abstract

PURPOSE

The association between GNB3 C825T polymorphism and cancer risk has been investigated. However, results remain inconclusive. In this study we aimed to obtain a more precise estimation of this association.

METHODS

A meta-analysis of 8 eligible studies including 1,812 cancer cases and 3,731 controls was conducted with odds ratios (ORs) and the corresponding 95% confidence interval (95% CI).

RESULTS

The results demonstrated a borderline association between the GNB3 C825T polymorphism and the risk of overall cancer in the dominant model (TT+TC vs CC, OR=1.13, 95% CI=1.00-1.28, PH=0.71, p=0.05). In the stratified analysis by cancer type, significant association of cancer risk was observed in thyroid carcinoma (TC vs CC, OR=1.26, 95% CI=1.02-1.54, PH=0.63, p=0.03; TT+TC vs CC, OR=1.24, 95% CI=1.02-1.51, PH=0.70, p=0.04). After further stratified analysis based on country, the GNB3 C825T polymorphism showed statistically significant association with increased risk of cancer in Austria (TT vs CC, OR=1.44, 95% CI=1.01-2.04, PH-0.88, p-0.04; TT vs TT+TC, OR=1.49, 95% CI=1.07-2.64, PH=0.87, p=0.02) and Germany (TC vs CC, OR=1.25, 95% CI=1.02-1.53; PH=0.87, p=0.03; TT+TC vs CC, OR=1.23, 95% CI=1.02-1.49, PH-0.90, p-0.04).

CONCLUSION

The current meta-analysis suggested that the GNB3 C825T polymorphism may contribute to increased risk of cancer, especially of thyroid carcinoma.

摘要

目的

已对GNB3基因C825T多态性与癌症风险之间的关联进行了研究。然而，结果仍无定论。在本研究中，我们旨在更精确地评估这种关联。

方法

对8项符合条件的研究进行荟萃分析，包括1812例癌症病例和3731例对照，计算比值比（OR）及相应的95%置信区间（95%CI）。

结果

结果显示，在显性模型中（TT+TC对比CC），GNB3基因C825T多态性与总体癌症风险之间存在临界关联（OR=1.13，95%CI=1.00-1.28，PH=0.71，p=0.05）。在按癌症类型进行的分层分析中，甲状腺癌的癌症风险存在显著关联（TC对比CC，OR=1.26，95%CI=1.02-1.54，PH=0.63，p=0.03；TT+TC对比CC，OR=1.24，95%CI=1.02-1.51，PH=0.70，p=0.04）。在基于国家进一步分层分析后，GNB3基因C825T多态性在奥地利（TT对比CC，OR=1.44，95%CI=1.01-2.04，PH=0.88，p=0.04；TT对比TT+TC，OR=1.49，95%CI=1.07-2.64，PH=0.87，p=0.02）和德国（TC对比CC，OR=1.25，95%CI=1.02-1.53；PH=0.87，p=0.03；TT+TC对比CC，OR=1.23，95%CI=1.