Garbino Nunzia, Brancato Valentina, Salvatore Marco, Cavaliere Carlo
IRCCS SDN, Naples, Italy.
Dose Response. 2021 Nov 24;19(4):15593258211056199. doi: 10.1177/15593258211056199. eCollection 2021 Oct-Dec.
Perfusion Computed Tomography (CTp) is an imaging technique which allows quantitative and qualitative evaluation of tissue perfusion through dynamic CT acquisitions. Since CTp is still considered a research tool in the field of abdominal imaging, the aim of this work is to provide a systematic summary of the current literature on CTp in the abdominal region to clarify the role of this technique for abdominal cancer applications.
A systematic literature search of PubMed, Web of Science, and Scopus was performed to identify original articles involving the use of CTp for clinical applications in abdominal cancer since 2011. Studies were included if they reported original data on CTp and investigated the clinical applications of CTp in abdominal cancer.
Fifty-seven studies were finally included in the study. Most of the included articles (33/57) dealt with CTp at the level of the liver, while a low number of studies investigated CTp for oncologic diseases involving UGI tract (8/57), pancreas (8/57), kidneys (3/57), and colon-rectum (5/57).
Our study revealed that CTp could be a valuable functional imaging tool in the field of abdominal oncology, particularly as a biomarker for monitoring the response to anti-tumoral treatment.
灌注计算机断层扫描（CTp）是一种成像技术，可通过动态CT采集对组织灌注进行定量和定性评估。由于CTp在腹部成像领域仍被视为一种研究工具，本研究的目的是对当前关于腹部CTp的文献进行系统总结，以阐明该技术在腹部癌症应用中的作用。
对PubMed、Web of Science和Scopus进行系统的文献检索，以识别自2011年以来涉及将CTp用于腹部癌症临床应用的原始文章。如果研究报告了关于CTp的原始数据并研究了CTp在腹部癌症中的临床应用，则纳入研究。
最终有57项研究纳入本研究。大多数纳入文章（33/57）涉及肝脏层面的CTp，而研究CTp用于上消化道（8/57）、胰腺（8/57）、肾脏（3/57）和结肠直肠（5/57）肿瘤疾病的研究数量较少。
我们的研究表明，CTp可能是腹部肿瘤学领域一种有价值的功能成像工具，特别是作为监测抗肿瘤治疗反应的生物标志物。
