Turk J Med Sci. 2014;44(2):249-54. doi: 10.3906/sag-1210-20.
To evaluate the prevalence of nocturia among different degrees of obstructive sleep apnea (OSA) and its association with various clinical conditions.
In 730 OSA patients, the prevalence and frequency of nocturia was determined, and the association of nocturia with clinical and laboratory variables such as the apnea-hypopnea index (AHI), apnea duration, and minimum oxygen saturation and clinical conditions such as diabetes mellitus, coronary heart disease, and chronic obstructive pulmonary disease (COPD) was determined.
The overall prevalence of nocturia (≥2 wakes/night) was 50.9%. Prevalences ofnocturia in simple snoring and mild, moderate, and severe OSA patients were 40.6%, 44.4%, 58.6%, and 57.1%, respectively (P < 0.005). The frequency of nocturia significantly increases with the severity of OSA (1.4 ± 1.0 wakes/night in mild OSA vs. 2.0 ? 1.4 wakes/night in severe OSA, P = 0.001). Age, AHI, average oxygen saturation, and presence of diabetes mellitus, hypertension, and COPD were found to be significant risk factors associated with nocturia (P <0.001).
The frequency of nocturia increases as the severity of OSA increase. The increased prevalence of nocturia in patients with OSA, diabetes mellitus, hypertension, and COPD indicates the complex physiological background of this bothersome urologic symptom.
评估不同程度阻塞性睡眠呼吸暂停（OSA）患者夜尿症的患病率及其与各种临床情况的关系。
在 730 例 OSA 患者中，确定夜尿症的患病率和频率，并确定夜尿症与临床和实验室变量（如呼吸暂停-低通气指数（AHI）、呼吸暂停持续时间和最低氧饱和度）以及糖尿病、冠心病和慢性阻塞性肺疾病（COPD）等临床情况的关系。
夜尿症（≥2 次/夜）的总患病率为 50.9%。单纯打鼾和轻度、中度和重度 OSA 患者的夜尿症患病率分别为 40.6%、44.4%、58.6%和 57.1%（P<0.005）。夜尿症的频率随着 OSA 的严重程度而显著增加（轻度 OSA 为 1.4±1.0 次/夜，重度 OSA 为 2.0±1.4 次/夜，P=0.001）。年龄、AHI、平均氧饱和度以及糖尿病、高血压和 COPD 的存在被发现是与夜尿症相关的显著危险因素（P<0.001）。
夜尿症的频率随着 OSA 严重程度的增加而增加。OSA、糖尿病、高血压和 COPD 患者夜尿症的患病率增加表明这种令人烦恼的泌尿科症状具有复杂的生理背景。
