Turk J Med Sci. 2014;44(2):323-9. doi: 10.3906/sag-1302-30.
To establish age- and sex-specific reference intervals for essential amino acids in a healthy Turkish pediatric population.
A total of 945 clinically healthy children (531 boys and 414 girls, ranging in age from birth to 14 years) were enrolled. Plasma and urine amino acids' concentrations were measured by high-performance liquid chromatography.
Concentrations of essential amino acids in plasma were higher in girls than in boys in the age groups of 0-1 months and 7-14 years; however, there was no difference in the other age groups. Concentrations of essential amino acids in urine were higher in girls than in boys in the age group of 0-1 months; however, there was no difference in the other age groups. Our results demonstrated the sex-related differences in concentrations ofleucine, isoleucine, valine, phenylalanine, lysine, and histidine in plasma, which increased with age in boys but not in girls. The concentrations of leucine, tryptophan, methionine, and lysine in urine declined with age in girls but not in boys, which were sex-related differences, too.
We defined essential amino acids' reference intervals in a Turkish pediatric population.
建立土耳其健康儿科人群必需氨基酸的年龄和性别特异性参考区间。
共纳入 945 名临床健康儿童（531 名男孩和 414 名女孩，年龄从出生到 14 岁不等）。通过高效液相色谱法测量血浆和尿液中氨基酸的浓度。
在 0-1 个月和 7-14 岁年龄组中，女孩血浆中必需氨基酸的浓度高于男孩；然而，在其他年龄组中没有差异。在 0-1 个月年龄组中，女孩尿液中必需氨基酸的浓度高于男孩；然而，在其他年龄组中没有差异。我们的结果表明，在男孩中，亮氨酸、异亮氨酸、缬氨酸、苯丙氨酸、赖氨酸和组氨酸的浓度随年龄增长而增加，但在女孩中没有这种性别相关的差异。在女孩中，尿液中亮氨酸、色氨酸、蛋氨酸和赖氨酸的浓度随年龄增长而下降，但在男孩中没有这种性别相关的差异。
我们在土耳其儿科人群中定义了必需氨基酸的参考区间。
