Aronova N V, Onoprienko N N, Tsimbalistova M V, Pavlovich N V
Zh Mikrobiol Epidemiol Immunobiol. 2014 Sep-Oct(5):32-7.
Comparative analysis of parameters of humoral and cell immunity in individuals, vaccinated against tularemia.
Sera and blood samples of 258 immunized individuals were studied by indirect hemagglutination and leukocytolis with tularin reaction.
73% of the examined individuals had both specific antibodies and positive values of cell immunity. The presence of anti-tularemia immunity was registered in 26 of 30 individuals immunized 10 - 20 years ago. However in 76 individuals (26%) we have detected discrepancies of the results of the 2 methods that complicate the evaluation of specific immunity status. As such, the use of only 1 method characterizing either humoral or cell immunity does not give objective information.
The use of 2 methods directed on detection of both specific antibodies and delayed-type hypersensitivity reaction is reasonable for the increase of validity of results of anti-tularemia immunity status evaluation. Only positive immunologic parameters of both tests confirm the presence of immunity against Francisella tularensjs and the possibility of revaccination period delay.
对接种兔热病疫苗个体的体液免疫和细胞免疫参数进行比较分析。
采用间接血凝试验和土拉菌素反应白细胞溶解法，对258名免疫个体的血清和血液样本进行研究。
73%的受检个体同时具有特异性抗体和细胞免疫阳性值。在10至20年前接种疫苗的30名个体中，有26人检测到存在抗兔热病免疫力。然而，在76名个体（26%）中，我们检测到两种方法的结果存在差异，这使得特异性免疫状态的评估变得复杂。因此，仅使用一种表征体液免疫或细胞免疫的方法并不能提供客观信息。
为提高抗兔热病免疫状态评估结果的有效性，采用两种方法检测特异性抗体和迟发型超敏反应是合理的。只有两种检测的免疫参数均为阳性，才能确认存在针对土拉热弗朗西斯菌的免疫力以及延长再次接种的间隔时间。
