Zeng Xianghui, Wang Liyun, Shu Xiaowei, Xiong Zhengfang, Dang Xiaohong
Medical Reproductive Center, Qinghai Province People's Hospital, Xining 810000, China.
Medical Reproductive Center, Qinghai Province People's Hospital, Xining 810000, China. Email:
Zhonghua Fu Chan Ke Za Zhi. 2014 Oct;49(10):763-7.
To study basic thyroid stimulating hormone (bTSH) levels impact on outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in Qinghai.
Totally 282 cases with IVF cycles and 93 cases with ICSI cycles were studied prospectively, according to bTSH level, patients were divided into four groups. Reproduction rate, clinical pregnancy rate, miscarriage rate and live birth rate were studied among four groups.
(1) In 375 cases with IVF/ICSI cycles, bTSH was positively correlated with abortion rate (r = 0.42, P = 0.04), but live birth rate and growing rate showed negative correlations with bTSH (r = -0.42, -0.28; P = 0.04, 0.03). bTSH and the number of eggs, the number of fertilized eggs, the number of embryos, biochemical pregnancy rate, and clinical pregnancy rate were no significant correlation (all P > 0.05). (2) Among women at group of ≤ 1.7, >1.7 and ≤ 2.5, >2.5 and ≤ 3.5, >3.5 mU/L, the implantation rates were 28.7%, 27.3%, 37.7% and 19.2%, live birth rates were 80.9%, 75.0%, 82.7%, and 59.8%, abortion rates were 19.0%, 15.0%, 16.7%, 40.1%; they all showed significant difference (all P < 0.05). Abortion rate in women with high bTSH level was higher than that of women with lower bTSH level, however implantation rate, live birth rate in women with high bTSH level were lower.
When bTSH level is >3.5 mU/L, the abortion rate were increased, but live birth rate, rate of implantation were decreased.
研究青海地区基础促甲状腺激素（bTSH）水平对体外受精（IVF）或卵胞浆内单精子注射（ICSI）结局的影响。
前瞻性研究282例IVF周期患者和93例ICSI周期患者，根据bTSH水平将患者分为四组。研究四组的生殖率、临床妊娠率、流产率和活产率。
（1）在375例IVF/ICSI周期患者中，bTSH与流产率呈正相关（r = 0.42，P = 0.04），但活产率和生长率与bTSH呈负相关（r = -0.42，-0.28；P = 0.04，0.03）。bTSH与卵子数、受精卵数、胚胎数、生化妊娠率和临床妊娠率无显著相关性（均P > 0.05）。（2）在bTSH水平≤1.7、>1.7且≤2.5、>2.5且≤3.5、>3.5 mU/L的女性中，种植率分别为28.7%、27.3%、3
