Cai YunYing, Zhong LanPing, Guan Jie, Guo RuiJin, Niu Ben, Ma YanPing, Su Heng
Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan Province, 650500, People's Republic of China.
Department of Endocrinology, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan, Kunming, Yunnan Province, 650032, People's Republic of China.
Reprod Biol Endocrinol. 2017 May 25;15(1):39. doi: 10.1186/s12958-017-0257-2.
Previous studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment. But IVF outcomes in treated SCH women whose serum Thyroid Stimulating Hormone (TSH) concentration did and did not exceed 2.5 mIU/L before the IVF cycle has not been studied thoroughly.
In this study, we performed a prospective cohort study with 270 treated subclinical hypothyroidism patients undergoing their first IVF retrieval cycle at a single cite.
SCH in women receiving LT4 replacement with a basal TSH level between 0.2-2.5mIU/L displayed a similar rate of clinical pregnancy (47.4% vs 38.7%, P = .436), miscarriage (7.4% vs 16.7%, P = .379) and live birth (43.9% vs 32.3%, P = .288) compared to women with a basal TSH level between 2.5-4.2 mIU/L.
Strictly controlled TSH (less than 2.5 mIU/L) before IVF may have no effect on the pregnancy rate in LT4 treated SCH women.
先前关于亚临床甲状腺功能减退症（SCH）与体外受精（IVF）结局之间关联的研究表明左甲状腺素（LT4）治疗有一些益处。但是，在IVF周期前血清促甲状腺激素（TSH）浓度是否超过2.5 mIU/L的接受治疗的SCH女性的IVF结局尚未得到充分研究。
在本研究中，我们进行了一项前瞻性队列研究，纳入了270例在单一中心接受首次IVF取卵周期的接受治疗的亚临床甲状腺功能减退症患者。
基础TSH水平在0.2 - 2.5 mIU/L之间接受LT4替代治疗的女性，与基础TSH水平在2.5 - 4.2 mIU/L之间的女性相比，临床妊娠率（47.4%对38.7%，P = 0.436）、流产率（7.4%对16.7%，P = 0.379）和活产率（43.9%对32.3%，P = 0.288）相似。
IVF前严格控制TSH（低于2.5 mIU/L）可能对接受LT4治疗的SCH女性的妊娠率没有影响。
