Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan,
Brain Tumor Pathol. 2015 Apr;32(2):99-104. doi: 10.1007/s10014-014-0211-3. Epub 2014 Dec 24.
The aim of this study was to determine if molecular alterations are associated with tumor location and radiological characteristics in anaplastic gliomas. We performed a retrospective analysis of 122 anaplastic gliomas for molecular alterations (IDH1/2 mutations, TP53 mutations, and 1p19q co-deletion) to compare MRI features (location and image characteristics). We observed that IDH mutation is strongly associated with frontal location (P = 0.001). However, 13 tumors not located in the cerebral cortex were IDH intact tumors (P < 0.0001). While IDH mutation and TP53 mutation are significantly associated with AA (p < 0.0001), IDH mutation and 1p19q co-deletion were significantly associated with AO/AOA (p < 0.0001). No tumors with IDH mutation and 1p19q co-deletion infiltrated the temporal lobe (P = 0.003). The tumors with 1p19q co-deletion and histologically diagnosed as AO/AOA were associated with contrast enhancement on MR images (p = 0.007, p = 0.002, respectively) and those with TP53 mutation had a weak association with sharp tumor borders (p = 0.043). MRI features might be useful to predict molecular profiles in anaplastic gliomas.
本研究旨在确定在间变性神经胶质瘤中，分子改变是否与肿瘤位置和放射影像学特征相关。我们对 122 例间变性神经胶质瘤进行了分子改变（IDH1/2 突变、TP53 突变和 1p19q 共缺失）的回顾性分析，以比较 MRI 特征（位置和影像特征）。我们发现 IDH 突变与额叶位置密切相关（P=0.001）。然而，13 例未位于大脑皮层的肿瘤为 IDH 完整型肿瘤（P<0.0001）。虽然 IDH 突变和 TP53 突变与 AA 显著相关（p<0.0001），但 IDH 突变和 1p19q 共缺失与 AO/AOA 显著相关（p<0.0001）。无 IDH 突变和 1p19q 共缺失的肿瘤浸润颞叶（P=0.003）。1p19q 共缺失且组织学诊断为 AO/AOA 的肿瘤与 MR 图像上的对比增强相关（p=0.007，p=0.002），而 TP53 突变与锐利肿瘤边界弱相关（p=0.043）。MRI 特征可能有助于预测间变性神经胶质瘤的分子谱。
