England Georgina, Heath Karen J, Gilbert John D, Byard Roger W
Forensic Science SA, 21 Divett Place, Adelaide, SA, 5000, Australia.
J Forensic Sci. 2015 Mar;60(2):341-5. doi: 10.1111/1556-4029.12679. Epub 2014 Dec 23.
Three cases of pharmacobezoars are reported to demonstrate typical autopsy findings and potential lethal mechanisms: (i) A 32-year-old woman died following an overdose of prescription medications. A gelatinous pharmacobezoar was found forming a cast of her bronchial tree. (ii) A 24-year-old woman also died following an overdose of prescription medications. At autopsy, two pharmacobezoars were present, one within the larynx and another occluding the right main bronchus. Deaths in both cases were attributed to airway occlusion by pharmacobezoars complicating mixed drug toxicity. (iii) A 79-year-old man was found dead in a car. Death was attributed to the combined effects of carbon monoxide and drug toxicity with a large pharmacobezoar lodged within the esophagus. Pharmacobezoars are specific types of bezoars that occur when pharmaceutical materials, such as tablets, suspensions, and/or drug delivery devices, aggregate and contribute to death by occluding airways with tenacious material or by eluting drugs.
报告了三例药物性胃石症病例，以展示典型的尸检结果和潜在的致死机制：（i）一名32岁女性因过量服用处方药死亡。发现一个凝胶状药物性胃石症形成了她支气管树的铸型。（ii）一名24岁女性也因过量服用处方药死亡。尸检时发现两个药物性胃石症，一个位于喉部，另一个阻塞右主支气管。这两例死亡均归因于药物性胃石症导致气道阻塞，并发混合药物中毒。（iii）一名79岁男性被发现死于车内。死亡归因于一氧化碳和药物毒性的联合作用，同时在食管内有一个大的药物性胃石症。药物性胃石症是胃石症的特定类型，当药物材料（如片剂、混悬剂和/或给药装置）聚集，并通过用粘性物质阻塞气道或通过药物洗脱导致死亡时就会发生。
