Kohl S, West M S, Prober C G, Sullender W M, Loo L S, Arvin A M
Department of Pediatrics University of Texas Medical School, Houston.
J Infect Dis. 1989 Nov;160(5):770-6. doi: 10.1093/infdis/160.5.770.
The role of antiviral antibodies in protection against neonatal herpes simplex virus (HSV) infection remains controversial. The relationship between neonatal and maternal anti-HSV antibodies and disease presentation was analyzed in 47 babies. Of the neonates, 77% had localized and 23% had disseminated HSV infection. Antibody-dependent cellular cytotoxic (ADCC) antibodies were evaluated in comparison with HSV neutralizing antibodies. High maternal (greater than 1:10(4)) or neonatal (greater than 1:10(3)) anti-HSV ADCC antibody levels or high neonatal antiviral neutralizing levels (greater than 1:20) were independently associated with an absence of disseminated HSV infection. Cochran-Mantel-Haenszel analysis demonstrated that ADCC levels were associated with disease status (P less than .02) while controlling for the level of neutralizing antibody.
抗病毒抗体在预防新生儿单纯疱疹病毒（HSV）感染中的作用仍存在争议。对47名婴儿的新生儿与母体抗HSV抗体及疾病表现之间的关系进行了分析。在这些新生儿中，77%患有局部HSV感染，23%患有播散性HSV感染。将抗体依赖性细胞毒性（ADCC）抗体与HSV中和抗体进行了评估比较。母体抗HSV ADCC抗体水平高（大于1:10⁴）或新生儿抗HSV ADCC抗体水平高（大于1:10³）或新生儿抗病毒中和水平高（大于1:20）均与无播散性HSV感染独立相关。 Cochr an-Mantel-Haenszel分析表明，在控制中和抗体水平的同时，ADCC水平与疾病状态相关（P小于0.02）。
