Ul Hassan Masood, Khan Shoukat H, Ashraf Mohd, Najar Saleem, Shaheen Feroz
Department of Nuclear Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
Department of Radiation Oncology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
World J Nucl Med. 2014 Sep;13(3):159-62. doi: 10.4103/1450-1147.144815.
To know the probability of renal artery stenosis (RAS) in unilateral small kidney and function of the unilateral small kidney, which includes glomerular filtration rate, differential function, uptake, Tmax by (99m)Tc diethylenetriaminepentacetic acid (DTPA) base and (99m)Tc DTPA angiotensin converting enzyme (ACE) inhibition scan. All our patients were subjected to (99m)Tc DTPA ACE inhibition renal scintigraphy. All the patients underwent either computed tomography (CT) angiography and magnetic resonance (MR) angiography was done in those patients in which kidney function test was deranged. Renal angiography was subsequently performed in cases with the suggestion of RAS on CT or MR angiography. The quantitative data was expressed as the arithmetic mean, standard deviation and percentages. The intergroup comparisons for parametric data were done by Student's t-test, whereas non-parametric data was compared with Mann-Whitney U-test. The intergroup comparisons were made by paired t-test and Wilcoxon sign rank test. P <0.05 was considered to be significant, and data was analyzed by Statistical package for social sciences(SPSS-20) software. Out of 47 patients, 25 patients were in the low probability group out of which none was positive for RAS on CT/MR angiography. Out of 47 patients, 12 were in the intermediate group out of which none was positive for RAS. Ten, out of 47 patients were suspected of high probability for RAS by ACE inhibition scan out of which 4 were positive for RAS by CT/MR angiography including one with bilateral RAS. (99m)Tc DTPA angiotension-coverting enzyme inhibitor renography is a safe, non-invasive, sensitive, specific, and cost-effective test for excluding renovascular hypertension in patients who have normal or nearly normal renal function in unilateral small kidney.
了解单侧小肾肾动脉狭窄（RAS）的概率以及单侧小肾的功能，包括肾小球滤过率、分肾功能、摄取、（99m）锝二乙三胺五乙酸（DTPA）基础上的Tmax以及（99m）锝DTPA血管紧张素转换酶（ACE）抑制扫描。我们所有的患者均接受了（99m）锝DTPA ACE抑制肾闪烁显像。所有患者均接受了计算机断层扫描（CT）血管造影，对于肾功能检查异常的患者进行了磁共振（MR）血管造影。随后，对CT或MR血管造影提示RAS的病例进行了肾血管造影。定量数据以算术平均值、标准差和百分比表示。参数数据的组间比较采用学生t检验，而非参数数据则与曼-惠特尼U检验进行比较。组间比较采用配对t检验和威尔科克森符号秩检验。P<0.05被认为具有统计学意义，数据采用社会科学统计软件包（SPSS-20）进行分析。在47例患者中，25例患者处于低概率组，其中CT/MR血管造影均未发现RAS阳性。在47例患者中，12例处于中间组，其中均未发现RAS阳性。47例患者中有10例通过ACE抑制扫描怀疑RAS概率高，其中4例CT/MR血管造影显示RAS阳性，包括1例双侧RAS。（99m）锝DTPA血管紧张素转换酶抑制剂肾图对于排除单侧小肾肾功能正常或接近正常患者的肾血管性高血压是一种安全、无创、敏感、特异且经济有效的检查。
