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使用β受体阻滞剂的未明确部位肾上腺外嗜铬细胞瘤患者的麻醉管理

Management of anesthesia in unspecified extra-adrenal pheochromocytoma patient who used beta-blocker.

作者信息

Ozer Ayse Belin, Demirel Ismail, Duzgol Ozgur, Ayten Refik, Erhan Omer Lutfi

机构信息

Department of Anesthesiology and Reanimation, Faculty of Medicine, Firat University, Elazig 23119, Turkey.

Department of General Surgery, Faculty of Medicine, Firat University, Elazig 23119, Turkey.

出版信息

Saudi J Anaesth. 2014 Nov;8(Suppl 1):S105-8. doi: 10.4103/1658-354X.144088.

DOI:10.4103/1658-354X.144088
PMID:25538499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4268506/
Abstract

An operation was planned for a female patient aged 59 for intra-abdominal mass. The patient was using nebivolol for hypertension. Blood pressure (BP) of the patient was raised to 200/130 mmHg during anesthesia induction. BP was gradually reduced by remifentanil infusion. Following the manipulation of the mass, BP began to increase (225/160 mmHg), thus nitroglycerin and followed nitroprusside infusion was started. Propofol (200 + 200 mg) and furosemide (20 mg) were administered intravenously. BP suddenly dropped (90/60 mmHg) following the removal of the mass, nitroglycerine, and nitroprusside infusions were stopped; remifentanil dose was decreased and fluid was quickly infused. The patient was uneventually recovered. Vanilmandelic acid level was higher in the patient and pheochromocytoma was considered.

摘要

计划为一名59岁的女性患者进行腹腔内肿块手术。该患者正在使用奈必洛尔治疗高血压。麻醉诱导期间患者血压升至200/130 mmHg。通过输注瑞芬太尼使血压逐渐降低。在对肿块进行操作后,血压开始升高(225/160 mmHg),于是开始输注硝酸甘油,随后又开始输注硝普钠。静脉注射丙泊酚(200 + 200 mg)和呋塞米(20 mg)。在切除肿块后血压突然下降(90/60 mmHg),停止输注硝酸甘油和硝普钠;减少瑞芬太尼剂量并快速输注液体。患者最终康复。患者香草扁桃酸水平较高,考虑为嗜铬细胞瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e654/4268506/3a135d6cd4d1/SJA-8-105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e654/4268506/3a135d6cd4d1/SJA-8-105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e654/4268506/3a135d6cd4d1/SJA-8-105-g001.jpg

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本文引用的文献

1
Perioperative management of pheochromocytoma/paraganglioma: is there a state of the art?嗜铬细胞瘤/副神经节瘤的围手术期管理:是否有最新进展?
Horm Metab Res. 2012 May;44(5):373-8. doi: 10.1055/s-0032-1306275. Epub 2012 Apr 19.
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Hypertensive crisis during wide excision of gastrointestinal stromal cell tumor (GIST): Undiagnosed paraganglioma -A case report-.胃肠道间质瘤(GIST)广泛切除术中的高血压危象:未诊断的副神经节瘤——病例报告。
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Point of controversy: perioperative care of patients undergoing pheochromocytoma removal-time for a reappraisal?
争议点:接受嗜铬细胞瘤切除术患者的围手术期护理——是否需要重新评估?
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Additive effect of propofol for attenuation of hypertension in a patient with undiagnosed phaeochromocytoma.丙泊酚对未确诊嗜铬细胞瘤患者高血压的降压增效作用。
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J Clin Endocrinol Metab. 2001 Apr;86(4):1480-6. doi: 10.1210/jcem.86.4.7392.
8
Normotensive pheochromocytoma. Pharmacologic, paraneoplastic and anesthetic considerations.血压正常的嗜铬细胞瘤。药理学、副肿瘤综合征及麻醉学考量
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Extra-adrenal pheochromocytoma.肾上腺外嗜铬细胞瘤
J Urol. 1992 Jan;147(1):1-10. doi: 10.1016/s0022-5347(17)37119-7.