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一种新颖的微流控流动聚焦方法。

A novel microfluidic flow focusing method.

机构信息

Department of Mechanical and Mechatronics Engineering, University of Waterloo , Waterloo, Ontario N2L 3G1, Canada.

出版信息

Biomicrofluidics. 2014 Oct 21;8(5):054120. doi: 10.1063/1.4899807. eCollection 2014 Sep.

DOI:10.1063/1.4899807
PMID:25538810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4241768/
Abstract

A new microfluidic method that allows hydrodynamic focusing in a microchannel with two sheath flows is demonstrated. The microchannel network consists of a T-shaped main channel and two T-shaped branch channels. The flows of the sample stream and the sheath streams in the microchannel are generated by electroosmotic flow-induced pressure gradients. In comparison with other flow focusing methods, this novel method does not expose the sample to electrical field, and does not need any external pumps, tubing, and valves.

摘要

本文展示了一种新的微流控方法,该方法允许在具有两个鞘流的微通道中进行流体动力学聚焦。微通道网络由 T 形主通道和两个 T 形分支通道组成。微通道中样品流和鞘流的流动是由电渗流引起的压力梯度产生的。与其他流聚焦方法相比,这种新方法不会使样品暴露于电场中,也不需要任何外部泵、管道和阀门。

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A novel microfluidic flow focusing method.一种新颖的微流控流动聚焦方法。
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2
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Micromachines (Basel). 2020 Aug 5;11(8):757. doi: 10.3390/mi11080757.
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A Microflow Cytometer with a Rectangular Quasi-Flat-Top Laser Spot.一种具有矩形准平顶激光光斑的微流控细胞仪。
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本文引用的文献

1
Continuous flow two-dimensional acoustic orientation of nonspherical cells.非球形细胞的连续流二维声学定向
Anal Chem. 2014 Jun 17;86(12):6111-4. doi: 10.1021/ac5012602. Epub 2014 Jun 6.
2
Sub-micrometer-precision, three-dimensional (3D) hydrodynamic focusing via "microfluidic drifting".亚微米精度的三维(3D)水力聚焦通过“微流漂移”实现。
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Microchip flow cytometry using electrokinetic focusing.采用电动聚焦的微芯片流式细胞术。
Anal Chem. 1999 Oct 1;71(19):4173-7. doi: 10.1021/ac990372u.
6
A hard microflow cytometer using groove-generated sheath flow for multiplexed bead and cell assays.一种使用槽式鞘流的硬微流控芯片,用于多重微球和细胞分析。
Anal Bioanal Chem. 2010 Nov;398(5):1871-81. doi: 10.1007/s00216-010-4019-7. Epub 2010 Jul 25.
7
Three-dimensional hydrodynamic focusing with a single sheath flow in a single-layer microfluidic device.在单层微流控装置中采用单鞘流的三维流体动力学聚焦。
Lab Chip. 2009 Nov 7;9(21):3155-60. doi: 10.1039/b910712f. Epub 2009 Aug 10.
8
Inertial microfluidics.惯性微流控技术。
Lab Chip. 2009 Nov 7;9(21):3038-46. doi: 10.1039/b912547g. Epub 2009 Sep 22.
9
A three-dimensional (3D) particle focusing channel using the positive dielectrophoresis (pDEP) guided by a dielectric structure between two planar electrodes.一种三维(3D)粒子聚焦通道,其利用由两个平面电极之间的介电结构引导的正介电泳(pDEP)。
Lab Chip. 2009 Mar 7;9(5):686-91. doi: 10.1039/b812213j. Epub 2008 Nov 24.
10
Two simple and rugged designs for creating microfluidic sheath flow.两种用于产生微流体鞘流的简单且坚固的设计。
Lab Chip. 2008 Jul;8(7):1097-103. doi: 10.1039/b719381e. Epub 2008 May 13.