Does the duration of action of angiotensin converting enzyme inhibitors affect their safety and adverse effects?

The results of more than 1600 patient years of experience with the new angiotensin converting enzyme (ACE) inhibitor, quinapril, suggest that it is safe for the treatment of hypertension and congestive heart failure. A once-daily regimen of quinapril minimizes adverse effects on renal function compared with a twice-daily regimen, and compared with enalapril. This may be because long-acting agents, or frequent doses of ACE inhibitors, produce a prolonged reduction in the glomerular filtration pressure.