• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[原发性非小细胞肺癌脑转移的治疗进展]

[Advances in treatment of brain metastases from primary non-small cell lung cancer].

作者信息

Lin Gen, Xu Haipeng, Huang Cheng

机构信息

Department of Medical Thoracic Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Teaching Hospital, 
Fuzhou 350014, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2014 Dec;17(12):877-83. doi: 10.3779/j.issn.1009-3419.2014.12.10.

DOI:10.3779/j.issn.1009-3419.2014.12.10
PMID:25539615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6000406/
Abstract

Metastatic tumors involving the brain are an important complication in the overall management of non-small cell lung cancers. Surgery and radiation remain the cornerstones of the therapy, however, the burgeoning knowledge of tumor biology has facilitated the entry of systemically administered therapies into the clinic. This review mainly summarizes the current applications of these data to surgery, radiation therapy, chemotherapy and targeted therapy.

摘要

涉及脑部的转移性肿瘤是非小细胞肺癌整体治疗中的一个重要并发症。手术和放疗仍然是治疗的基石，然而，肿瘤生物学知识的不断涌现促进了全身给药疗法进入临床。本综述主要总结了这些数据在手术、放疗、化疗和靶向治疗中的当前应用。

相似文献

1
[Advances in treatment of brain metastases from primary non-small cell lung cancer].[原发性非小细胞肺癌脑转移的治疗进展]
Zhongguo Fei Ai Za Zhi. 2014 Dec;17(12):877-83. doi: 10.3779/j.issn.1009-3419.2014.12.10.
2
Gamma knife treatment for multiple metastatic brain tumors compared with whole-brain radiation therapy.伽玛刀治疗多发性脑转移瘤与全脑放射治疗的比较。
J Neurosurg. 2000 Dec;93 Suppl 3:32-6. doi: 10.3171/jns.2000.93.supplement.
3
Brain metastases in small cell lung cancer.小细胞肺癌的脑转移
Oncology (Williston Park). 2004 Jul;18(8):961-72; discussion 974, 979-80, 987.
4
Controversies in the management of patients with brain metastases.脑转移瘤患者管理中的争议
Cancer J. 2001 Mar-Apr;7(2):105-7.
5
Current approaches to the treatment of metastatic brain tumours.转移性脑肿瘤的当前治疗方法。
Nat Rev Clin Oncol. 2014 Apr;11(4):203-22. doi: 10.1038/nrclinonc.2014.25. Epub 2014 Feb 25.
6
Time for reappraisal of extracranial treatment options? Synchronous brain metastases from nonsmall cell lung cancer.是否需要重新评估颅外治疗方案？非小细胞肺癌的同步性脑转移。
Cancer. 2011 Feb 1;117(3):597-605. doi: 10.1002/cncr.25416. Epub 2010 Sep 24.
7
Stereotactic radiosurgery for the management of brain metastases.立体定向放射外科治疗脑转移瘤
N Engl J Med. 2010 Mar 25;362(12):1119-27. doi: 10.1056/NEJMct0806951.
8
Treatment outcome for patients with primary nonsmall-cell lung cancer and synchronous brain metastasis.原发性非小细胞肺癌合并同步脑转移患者的治疗结果。
Radiat Oncol Investig. 1999;7(5):313-9. doi: 10.1002/(SICI)1520-6823(1999)7:5<313::AID-ROI7>3.0.CO;2-9.
9
Prolonged survival after resection and radiotherapy for solitary brain metastases from non-small-cell lung cancer.非小细胞肺癌孤立性脑转移瘤切除术后联合放疗后的长期生存
Australas Radiol. 2007 Apr;51(2):186-9. doi: 10.1111/j.1440-1673.2007.01702.x.
10
Hypofractionated stereotactic radiotherapy with or without whole-brain radiotherapy for patients with newly diagnosed brain metastases from non-small cell lung cancer.立体定向放射治疗与或不与全脑放疗治疗非小细胞肺癌脑转移患者的新诊断病例。
J Neurosurg. 2012 Dec;117 Suppl:49-56. doi: 10.3171/2012.7.GKS121071.

引用本文的文献

1
[Advances in Bevacizumab Therapy for Non-small Cell Lung Cancer 
with Brain Metastases].[贝伐单抗治疗非小细胞肺癌脑转移的研究进展]
Zhongguo Fei Ai Za Zhi. 2016 Aug 20;19(8):515-8. doi: 10.3779/j.issn.1009-3419.2016.08.05.
2
Adaptive hypofractionated gamma knife radiosurgery for a large brainstem metastasis.自适应大分割伽玛刀放射外科治疗脑干大转移瘤。
Surg Neurol Int. 2016 Feb 10;7(Suppl 4):S130-8. doi: 10.4103/2152-7806.176138. eCollection 2016.

本文引用的文献

1
Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole-brain radiation therapy versus WBRT plus stereotactic radiosurgery in patients with 1-3 brain metastases; poststratified by the graded prognostic assessment (GPA).RTOG 9508的二次分析，这是一项3期随机试验，比较全脑放射治疗与全脑放射治疗加立体定向放射外科治疗1-3个脑转移瘤患者的疗效；按分级预后评估（GPA）进行分层后分析。
Int J Radiat Oncol Biol Phys. 2014 Nov 1;90(3):526-31. doi: 10.1016/j.ijrobp.2014.07.002. Epub 2014 Sep 26.
2
Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study.立体定向放射外科治疗多发性脑转移瘤（JLGK0901）：一项多机构前瞻性观察研究。
Lancet Oncol. 2014 Apr;15(4):387-95. doi: 10.1016/S1470-2045(14)70061-0. Epub 2014 Mar 10.
3
Gamma Knife radiosurgery to four or more brain metastases in patients without prior intracranial radiation or surgery.对未经颅内放疗或手术的患者进行伽玛刀放射外科治疗四个或更多脑转移瘤。
Cancer Med. 2014 Jun;3(3):565-71. doi: 10.1002/cam4.206. Epub 2014 Feb 10.
4
EGFR mutation and brain metastasis in pulmonary adenocarcinomas.肺腺癌中的 EGFR 突变与脑转移。
J Thorac Oncol. 2014 Feb;9(2):195-9. doi: 10.1097/JTO.0000000000000069.
5
Chemotherapy and EGFR tyrosine kinase inhibitors for treatment of brain metastases from non-small-cell lung cancer: survival analysis in 210 patients.化疗和表皮生长因子受体酪氨酸激酶抑制剂治疗非小细胞肺癌脑转移：210 例患者的生存分析。
Onco Targets Ther. 2013 Dec 4;6:1789-803. doi: 10.2147/OTT.S52172. eCollection 2013.
6
Role of stereotactic radiosurgery in patients with more than four brain metastases.立体定向放射外科在脑转移瘤超过4个的患者中的作用。
CNS Oncol. 2013 Mar;2(2):181-93. doi: 10.2217/cns.13.4.
7
Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma.表皮生长因子受体突变型肺腺癌脑转移日本患者单独使用吉非替尼而不进行放射治疗的 II 期试验。
Lung Cancer. 2013 Nov;82(2):282-7. doi: 10.1016/j.lungcan.2013.08.016. Epub 2013 Aug 28.
8
Pharmacokinetic and pharmacodynamic study of Gefitinib in a mouse model of non-small-cell lung carcinoma with brain metastasis.吉非替尼在伴有脑转移的非小细胞肺癌小鼠模型中的药代动力学和药效学研究。
Lung Cancer. 2013 Nov;82(2):313-8. doi: 10.1016/j.lungcan.2013.08.013. Epub 2013 Aug 19.
9
Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group.临床研究中与实体瘤脑转移瘤相关的挑战，第 2 部分：神经认知、神经和生活质量结局。RANO 小组的报告。
Lancet Oncol. 2013 Sep;14(10):e407-16. doi: 10.1016/S1470-2045(13)70308-5.
10
Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group.临床试验中与实体瘤脑转移相关的挑战，第 1 部分：患者人群、反应和进展。 RANO 小组的报告。
Lancet Oncol. 2013 Sep;14(10):e396-406. doi: 10.1016/S1470-2045(13)70311-5.