Centre for NanoScale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA 5042, Australia.
School of Biological Sciences, Flinders University, Bedford Park, SA 5042, Australia.
J Colloid Interface Sci. 2015 Apr 1;443:88-96. doi: 10.1016/j.jcis.2014.11.043. Epub 2014 Nov 25.
Ramizol® (1,3,5-tris[(1E)-2'-(4'-benzoic acid)vinyl]benzene) is a potent amphiphilic anti-microbial agent. It is essentially a planar molecule and can interact with the surface of graphene via extended π-π interactions. Herein we demonstrate the utility of Ramizol® in potentially acting as a molecular 'wedge' to exfoliate graphene and stabilise it in water. The non-covalent attachment of Ramizol® on the graphene surface enables release of Ramizol® by altering the pH of the solution. Furthermore, the stabilised composite material demonstrates antibacterial activity against Staphylococcus aureus which leads to potential in biomedical applications with graphene acting as a drug carrier as well as enhancing the structural strength of the composite material.
拉米唑(1,3,5-三[(1E)-2'-(4'-苯甲酸)乙烯基]苯)是一种有效的两亲性抗菌剂。它本质上是一个平面分子,可以通过扩展的π-π相互作用与石墨烯表面相互作用。在此,我们证明了拉米唑在潜在地作为分子“楔子”来剥离石墨烯并使其在水中稳定的用途。拉米唑通过改变溶液的 pH 值在石墨烯表面的非共价附着可以使拉米唑释放。此外,稳定的复合材料对金黄色葡萄球菌表现出抗菌活性,这使得石墨烯作为药物载体以及增强复合材料的结构强度具有潜在的生物医学应用。