豚鼠（豚鼠科；豚鼠属）骨关节炎模型的全线粒体基因组序列
Whole mitochondrial genome sequence for an osteoarthritis model of Guinea pig (Caviidae; Cavia).
作者信息
Cui Xin-Gang, Liu Cheng-Yao, Wei Bo, Zhao Wen-Jian, Zhang Wen-Feng
机构信息
a Department of Spine , Provincial Hospital Affiliated to Shandong University , Jinan , China.
b Department of Orthopedics , The People's Hospital of Zhangqiu , Jinan , China , and.
出版信息
Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Nov;27(6):3915-3916. doi: 10.3109/19401736.2014.987263. Epub 2014 Dec 26.
Animal models played an important role in osteoarthritis studies. Here, the complete mitochondrial genome sequence of the Guinea pig was reported for the first time. The total length of the mitogenome was 16,797 bp. It contained the typical structure, including two ribosomal RNA genes, 13 protein-coding genes, 22 transfer RNA genes and one non-coding control region (D-loop region). The overall composition of the mitogenome was estimated to be 34.9% for A, 26.1% for T, 26.0% for C and 13.0% for G showing an A-T (61.0%)-rich feature. This mitochondrial genome sequence will provide new genetic resource into osteoarthritis disease.
动物模型在骨关节炎研究中发挥了重要作用。在此，首次报道了豚鼠的完整线粒体基因组序列。该线粒体基因组全长16,797 bp。它包含典型的结构，包括两个核糖体RNA基因、13个蛋白质编码基因、22个转运RNA基因和一个非编码控制区（D环区）。线粒体基因组的总体组成估计为A占34.9%、T占26.1%、C占26.0%、G占13.0%，呈现出富含A-T（61.0%）的特征。该线粒体基因组序列将为骨关节炎疾病提供新的遗传资源。
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