自发小鼠骨关节炎模型DBA/1品系的全线粒体基因组序列
Whole mitochondrial genome sequence for an osteoarthritis model of spontaneous mice DBA/1 strain.
作者信息
Cui Xin-Gang, Wang Fu, Sun Jian-Min, Jiang Zhen-Song, Wang Yan, Yang Xiao-Xia
机构信息
a Department of Spine and.
b Department of Traumatic Orthopaedics , Provincial Hospital Affiliated to Shandong University , Jinan , China , and.
出版信息
Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Nov;27(6):4142-4143. doi: 10.3109/19401736.2014.1003882. Epub 2015 Mar 23.
Animal models play an important role in osteoarthritis studies. Here, the complete mitochondrial genome sequence of the spontaneous mice DBA/1 strain was reported for the first time. The total length of the mitogenome was 16,769 bp. It contained the typical structure, including two ribosomal RNA genes, 13 protein-coding genes, 22 transfer RNA genes, and one non-coding control region (D-loop region). The overall GC content of the mitogenome was estimated to be 39.2%. This mitochondrial genome sequence will provide new genetic resource into osteoarthritis disease.
动物模型在骨关节炎研究中发挥着重要作用。在此，首次报道了自发性小鼠DBA/1品系的完整线粒体基因组序列。线粒体基因组全长16,769 bp。它包含典型结构，包括两个核糖体RNA基因、13个蛋白质编码基因、22个转运RNA基因和一个非编码控制区（D环区）。线粒体基因组的总体GC含量估计为39.2%。该线粒体基因组序列将为骨关节炎疾病提供新的遗传资源。
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