慢性阻塞性肺疾病大鼠模型的全线粒体基因组测序与分析
Whole mitochondrial genome sequencing and analysis for chronic obstructive pulmonary disease rat strain.
作者信息
Jiang Zhi-Ming, Zhao Qing-Sheng, Xu Yong-Qing, Li Tao, Jie Jian, Zhang Zhong-Hui
机构信息
a Department of Critical-care Medicine , Qianfoshan Hospital affiliated to Shandong University , Jinan , China and.
b Department of Thoracic Surgery , The People's Hospital of Linyi , Linyi , China.
出版信息
Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Nov;27(6):3917-3918. doi: 10.3109/19401736.2014.987264. Epub 2014 Dec 26.
Mitochondrial genome plays a central role in aging, cancer, apoptosis and metabolism. We sequenced a complete mitochondrial genome sequence of a rat chronic obstructive pulmonary disease rat strain for the first time. The total length of the mitochondrial genome was 16,310 bp and coding 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes. This genome describing information will supply the potential use of mtDNA mutations as markers in cancer.
线粒体基因组在衰老、癌症、细胞凋亡和新陈代谢中起着核心作用。我们首次对大鼠慢性阻塞性肺疾病大鼠品系的线粒体基因组序列进行了完整测序。线粒体基因组全长16310bp，编码13个蛋白质编码基因、2个核糖体RNA基因和22个转运RNA基因。这些基因组描述信息将为线粒体DNA突变作为癌症标志物的潜在应用提供依据。
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