Division of Endocrinology and Metabolism, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Diabetes Metab J. 2014 Dec;38(6):449-55. doi: 10.4093/dmj.2014.38.6.449. Epub 2014 Dec 15.
The aim of this study was to investigate whether adjusting diabetic treatment regimens according to the information obtained from a continuous glucose monitoring system (CGMS) might lead to improved glycemic control in patients with type 2 diabetes.
We reviewed the medical charts of 172 patients who used the CGMS for 1 year starting in December 2008 and the records of 1,500 patients who visited their regular outpatient clinics during December 2008. Of these patients, a total of 65 CGMS patients and 301 regular outpatients (control group) were enrolled in the study after propensity score matching. There were no differences in baseline glycated hemoglobin (HbA1c), age, and duration of diabetes between the CGMS and the control groups after propensity score matching. The changes in the HbA1c levels from baseline to 6 months were calculated.
The CGMS group showed a significant improvement in the HbA1c level compared to the control group at 3 months (7.9%±1.6% vs. 7.4%±1.2%, P=0.001) and at 6 months (7.4%±1.2% vs. 7.9%±1.6%, P=0.010). There were significant differences in the treatment modality changes between the CGMS group and the control group.
Using a 3-day CGMS was advantageous for improving glucose control in patients with type 2 diabetes and may help these patients to optimize glycemic control in clinical practice.
本研究旨在探讨根据连续血糖监测系统(CGMS)获得的信息调整糖尿病治疗方案是否可以改善 2 型糖尿病患者的血糖控制。
我们回顾了自 2008 年 12 月开始使用 CGMS 进行 1 年的 172 名患者的病历记录和 2008 年 12 月期间就诊于常规门诊的 1500 名患者的记录。在这些患者中,共对 65 名 CGMS 患者和 301 名常规门诊患者(对照组)进行了倾向评分匹配研究。在倾向评分匹配后,CGMS 组和对照组的基线糖化血红蛋白(HbA1c)、年龄和糖尿病病程无差异。计算从基线到 6 个月时 HbA1c 水平的变化。
与对照组相比,CGMS 组在 3 个月(7.9%±1.6%比 7.4%±1.2%,P=0.001)和 6 个月(7.4%±1.2%比 7.9%±1.6%,P=0.010)时 HbA1c 水平显著改善。CGMS 组和对照组之间的治疗方式变化存在显著差异。
使用 3 天 CGMS 有利于改善 2 型糖尿病患者的血糖控制,并且可能有助于这些患者在临床实践中优化血糖控制。