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持续葡萄糖监测在青少年起病的2型糖尿病中的应用。

Use of Continuous Glucose Monitoring in Youth-Onset Type 2 Diabetes.

作者信息

Chan Christine L

机构信息

Department of Pediatrics, Endocrinology, University of Colorado School of Medicine, Children's Hospital Colorado, 13123 E. 16th Avenue, Aurora, CO, 80045, USA.

出版信息

Curr Diab Rep. 2017 Sep;17(9):66. doi: 10.1007/s11892-017-0905-0.

Abstract

PURPOSE OF REVIEW

Continuous glucose monitoring (CGM) technology has long been accepted as a tool for managing glycemia in type 1 diabetes (T1D) and is receiving increased attention as a tool for monitoring glucose patterns in patients with other forms of diabetes, in particular type 2 diabetes (T2D). Recent studies in adults with T2D have shown benefits of CGM in the investigation of glycemic variability, as well as utility as a tool for improving glycemic control. The literature on CGM use in youth-onset T2D, however, is sparse. This paper reviews the various roles for CGM in T2D, with a focus on published reports of CGM use in youth-onset T2D. The gaps in knowledge are highlighted, along with a discussion regarding need for future studies of potential applications for CGM in this younger population.

RECENT FINDINGS

CGM systems provide insight into glycemic abnormalities in obese youth with and at risk for T2D. This technology has enabled examination of the relationship between free-living glycemic profiles and traditional diabetes screening tests, as well as markers of cardiometabolic risk in this high-risk population. Investigators are incorporating CGM technology into the study of T2D in youth, but interventional studies of CGM as a tool for glycemic control in youth-onset T2D are limited. Youth with T2D face a more aggressive disease than adults with T2D, and further studies utilizing advances in glucose monitoring technology to improve outcomes in this population are needed.

摘要

综述目的

长期以来,持续葡萄糖监测(CGM)技术一直被视为管理1型糖尿病(T1D)血糖的工具,并且作为监测其他类型糖尿病患者,尤其是2型糖尿病(T2D)患者血糖模式的工具正受到越来越多的关注。最近针对成年T2D患者的研究表明,CGM在调查血糖变异性方面具有益处,并且作为改善血糖控制的工具也具有实用性。然而,关于CGM在青少年起病的T2D中应用的文献却很少。本文综述了CGM在T2D中的各种作用,重点关注已发表的关于CGM在青少年起病的T2D中应用的报告。文中突出了知识空白,并讨论了针对这一年轻人群对CGM潜在应用进行未来研究的必要性。

最新发现

CGM系统有助于深入了解患有T2D及有T2D风险的肥胖青少年的血糖异常情况。这项技术能够研究自由生活状态下的血糖谱与传统糖尿病筛查测试之间的关系,以及该高危人群中心血管代谢风险的标志物。研究人员正在将CGM技术纳入青少年T2D的研究中,但将CGM作为青少年起病的T2D血糖控制工具的干预性研究有限。患有T2D的青少年面临的疾病比成年T2D患者更为严重,因此需要进一步利用血糖监测技术的进展来改善该人群的治疗效果。

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