人扁桃体的光学相干断层扫描和自发荧光成像
Optical coherence tomography and autofluorescence imaging of human tonsil.
作者信息
Pahlevaninezhad Hamid, Lee Anthony M D, Rosin Miriam, Sun Ivan, Zhang Lewei, Hakimi Mehrnoush, MacAulay Calum, Lane Pierre M
机构信息
Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
Department of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
PLoS One. 2014 Dec 26;9(12):e115889. doi: 10.1371/journal.pone.0115889. eCollection 2014.
For the first time, we present co-registered autofluorescence imaging and optical coherence tomography (AF/OCT) of excised human palatine tonsils to evaluate the capabilities of OCT to visualize tonsil tissue components. Despite limited penetration depth, OCT can provide detailed structural information about tonsil tissue with much higher resolution than that of computed tomography, magnetic resonance imaging, and Ultrasound. Different tonsil tissue components such as epithelium, dense connective tissue, lymphoid nodules, and crypts can be visualized by OCT. The co-registered AF imaging can provide matching biochemical information. AF/OCT scans may provide a non-invasive tool for detecting tonsillar cancers and for studying the natural history of their development.
首次，我们展示了切除的人类腭扁桃体的共配准自体荧光成像和光学相干断层扫描（AF/OCT），以评估光学相干断层扫描（OCT）可视化扁桃体组织成分的能力。尽管穿透深度有限，但与计算机断层扫描、磁共振成像和超声相比，光学相干断层扫描（OCT）能够以更高的分辨率提供有关扁桃体组织的详细结构信息。光学相干断层扫描（OCT）可以可视化不同的扁桃体组织成分，如上皮、致密结缔组织、淋巴小结和隐窝。共配准的自体荧光成像（AF）可以提供匹配的生化信息。AF/OCT扫描可能为检测扁桃体癌和研究其发展的自然史提供一种非侵入性工具。
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