Chodakowska J, Wocial B, Ignatowska-Switalska H, Knypl K, Brym E, Czerniewska E, Wacławek-Maczkowska J, Jabłońska-Skwiecińska E, Drygieniec D, Januszewicz W
Pol Tyg Lek. 1989;44(12-13):297-300.
An effect of enalapril maleate on the activity of renin-angiotensin-aldosterone system and sympathetic reactivity, erythrocyte prostaglandin and sodium levels as well as blood beta-endorphin was investigated in 28 patients with the essential arterial blood hypertension. It was found that enalapril maleate significantly increased plasma renin activity, decreased plasma norepinephrine and its 24-hour excretion, and decreased erythrocyte beta-endorphin and sodium levels. Blood epinephrine and aldosterone levels and their daily excretion remained unchanged similarly to prostaglandins. The above results suggest that a decrease in sympathetic system activity and intracellular sodium concentration may play a role in the hypotensive action of enalapril maleate related to the inhibition of angiotensin II formation.
对28例原发性动脉高血压患者研究了马来酸依那普利对肾素 - 血管紧张素 - 醛固酮系统活性、交感反应性、红细胞前列腺素和钠水平以及血液β - 内啡肽的影响。结果发现，马来酸依那普利显著增加血浆肾素活性，降低血浆去甲肾上腺素及其24小时排泄量，并降低红细胞β - 内啡肽和钠水平。血肾上腺素和醛固酮水平及其每日排泄量与前列腺素一样保持不变。上述结果表明，交感神经系统活性和细胞内钠浓度的降低可能在马来酸依那普利与抑制血管紧张素II形成相关的降压作用中起作用。
