Smrcková I, Stríbrná J, Petrásek R, Skibová J, Lánská V
Institut klinické a experimentální medicíny, Praha.
Cas Lek Cesk. 1992 May 25;131(10):294-6.
The authors investigated in ten patients with essential hypertension changes in the membrane transport of sodium in red blood cells and the intracellular calcium content of thrombocytes during the control period during treatment of hypertension with central sympatholytics and after three-week treatment with an inhibitor of the angiotensin converting enzyme (ACE), enalapril. The effect of enalapril in hypertonic patients was manifested by a rise of the renin plasma activity and the potassium concentration and a reduction of the sodium plasma concentration which corresponds to the inhibition of angiotensin II. The intracellular calcium and sodium content was unaltered. In 8 of 10 patients after enalapril treatment increased values of Vmax for Na(+)-K+ cotransport occurred, incl. 6 patients where at the same time a rise of Vmax Na(+)-Li+ countertransport was recorded.
作者对10例原发性高血压患者进行了研究，观察了在高血压治疗的对照期、使用中枢性抗交感神经药治疗期间以及使用血管紧张素转换酶（ACE）抑制剂依那普利进行三周治疗后，红细胞膜钠转运和血小板细胞内钙含量的变化。依那普利对高血压患者的作用表现为血浆肾素活性和钾浓度升高，血浆钠浓度降低，这与血管紧张素II的抑制作用相符。细胞内钙和钠含量未发生改变。10例患者中有8例在依那普利治疗后出现Na(+)-K+协同转运的Vmax值升高，其中6例同时记录到Na(+)-Li+逆向转运的Vmax升高。
