Sakurai-Yamashita Y, Kataoka Y, Fujiwara M, Mine K, Ueki S
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences Fukuoka University, Japan.
Pharmacol Biochem Behav. 1989 Jun;33(2):397-400. doi: 10.1016/0091-3057(89)90521-2.
We examined the effects of delta 9-tetrahydrocannabinol (THC) on striatal dopaminergic neurons in rats. THC inhibited the uptake of 3H-dopamine (DA) into striatal synaptosomes. THC facilitated the release of endogenous DA but not dihydroxyphenylacetic acid (DOPAC) from striatal slices. The concentration of DA in the dorsolateral striatum was reduced by THC. We propose that THC may stimulate nigrostriatal dopaminergic neurotransmission mainly by inhibiting uptake of DA and by facilitating release of DA.
我们研究了δ9-四氢大麻酚（THC）对大鼠纹状体多巴胺能神经元的影响。THC抑制了3H-多巴胺（DA）向纹状体突触体的摄取。THC促进了内源性DA从纹状体切片中的释放，但对二羟基苯乙酸（DOPAC）无此作用。THC降低了背外侧纹状体中DA的浓度。我们提出，THC可能主要通过抑制DA摄取和促进DA释放来刺激黑质纹状体多巴胺能神经传递。
