Husain S, Patra P B
Department of Pharmacology, University of North Dakota, School of Medicine, Grand Forks 58201.
Physiol Behav. 1989 Jul;46(1):61-4. doi: 10.1016/0031-9384(89)90322-3.
In this study, the combined effects of chronic phencyclidine (PCP) and delta 9-tetrahydrocannabinol on spermatogenesis in mice were examined. Mice were treated with THC (50 mg/kg, PO) and PCP (15 mg/kg, IP) alone or in combination for 16 days and with PCP alone for 35 days. THC had a significant effect on spermatogenesis and decreased the number of all germinal cells. PCP, on the other hand, affected all germinal cells except spermatids after 35 days of treatment. Combination of THC and PCP treatment caused a significant decrease in resting and pachytene spermatocytes. Similarly, combination of these two drugs caused a significant increase in cauda epididymal abnormal sperms. These results suggest that THC and PCP may cause greater disruption in spermatogenesis when they are abused together.
在本研究中，检测了慢性苯环利定（PCP）和Δ9-四氢大麻酚对小鼠精子发生的联合作用。小鼠单独或联合接受四氢大麻酚（50毫克/千克，口服）和苯环利定（15毫克/千克，腹腔注射）处理16天，以及单独接受苯环利定处理35天。四氢大麻酚对精子发生有显著影响，并减少了所有生殖细胞的数量。另一方面，在处理35天后，苯环利定影响了除精子细胞外的所有生殖细胞。四氢大麻酚和苯环利定联合处理导致静止期和粗线期精母细胞显著减少。同样，这两种药物联合使用导致附睾尾部异常精子显著增加。这些结果表明，四氢大麻酚和苯环利定一起滥用时，可能对精子发生造成更大的破坏。
