Freeman A S, Martin B R
Life Sci. 1983 Mar 7;32(10):1081-9. doi: 10.1016/0024-3205(83)90113-3.
The behavioral and pharmacological interactions between delta 9-tetrahydrocannabinol (delta 9-THC) and phencyclidine (PCP) were studied following coadministration of the drugs in smoke to mice. While delta 9-THC (25, 50 or 100 mg/cigarette) had little effect on spontaneous motor activity, all doses attenuated the hyperactivity elicited by PCP X HCl (25 and 50 mg/cigarette). delta 9-THC produced a dose-related hypothermia. PCP X HCl (50 mg/cigarette) had no effect on body temperature but enhanced hypothermia when combined with 25 mg of delta 9-THC. delta 9-THC (100 mg/cigarette) had no effect on the biodisposition of 3H-PCP and its pyrolytic product, 3H-phenylcyclohexene (3H-PC), when examined immediately after 3H-PCP X HCl (50 mg/ cigarette) exposure. At 30 min, brain, liver, lung and plasma contained higher concentrations of 3H-PC and fat and plasma contained lower concentrations of 3H-PCP in the mice exposed to both drugs compared to 3H-PCP X HCl alone. It appears, therefore, that delta 9-THC has the potential for altering the behavioral, pharmacological and pharmacokinetic sequelae of PCP abuse.
在将δ9 - 四氢大麻酚（δ9 - THC）和苯环利定（PCP）以烟雾形式共同给予小鼠后，对它们之间的行为和药理相互作用进行了研究。虽然δ9 - THC（25、50或100毫克/支香烟）对自发运动活动影响不大，但所有剂量均减弱了盐酸苯环利定（PCP X HCl，25和50毫克/支香烟）引起的多动。δ9 - THC产生剂量相关的体温过低。盐酸苯环利定（PCP X HCl，50毫克/支香烟）对体温没有影响，但与25毫克δ9 - THC联合使用时会增强体温过低。在暴露于盐酸3H - 苯环利定（3H - PCP X HCl，50毫克/支香烟）后立即检查时，δ9 - THC（100毫克/支香烟）对3H - PCP及其热解产物3H - 苯基环己烯（3H - PC）的生物处置没有影响。30分钟时，与单独暴露于盐酸3H - 苯环利定相比，同时暴露于两种药物的小鼠的脑、肝、肺和血浆中3H - PC的浓度较高，脂肪和血浆中3H - PCP的浓度较低。因此，似乎δ9 - THC有可能改变PCP滥用的行为、药理和药代动力学后果。
