Gebremedhin Samson
School of Public and Environmental Health,Hawassa University,Hawassa,Ethiopia.
Twin Res Hum Genet. 2015 Feb;18(1):100-7. doi: 10.1017/thg.2014.82. Epub 2014 Dec 29.
The study endeavored to assess the epidemiology, postnatal survival, and growth pattern of multiple births in Sub-Saharan Africa (SSA). It was based on the data of 25 demographic health surveys conducted in the subcontinent since 2008. The records of 213,889 children born in the preceding 59 months of the surveys were included. The multiple birth rate was computed as the number of multiple confinements per 1,000 births. Factors associated with multiple births were identified using logistic regression and their survival pattern was assessed using the Kaplan-Meier method. The multiple birth rate was 17.1 (95% confidence interval: 17.7-16.6) and showed considerable variation across the 25 countries included in the study. Odds of multiple births were significantly increased with advanced maternal age, parity, and maternal height but not with wealth index, age at first birth, and month of birth. At the end of the fourth year of age, the cumulative survival probability was as low as 0.77 in multiple births as compared to 0.93 in their counterparts. The odds of neonatal, infant and under-five mortality were 5.55, 4.39, and 3.72 times increased in multiple births, respectively. Multiple births tend to be malnourished than singletons and the odds of wasting, stunting, and underweight were 1.31, 1.83, and 1.73 times raised, consecutively. Nevertheless, multiple births regain their weight-for-age (WFA) and height-for-age (HFA) deficits by the end of the fourth year of age. Counseling pregnant mothers with multiple gestation to give birth at a health institution and providing close medical follow-up during and after the neonatal period can improve the survival of multiple births.
该研究旨在评估撒哈拉以南非洲地区(SSA)多胞胎的流行病学、出生后存活率及生长模式。研究基于自2008年以来在该次大陆进行的25次人口健康调查数据。纳入了调查前59个月内出生的213,889名儿童的记录。多胞胎出生率计算为每1000例出生中的多胞胎分娩数。使用逻辑回归确定与多胞胎相关的因素,并使用Kaplan-Meier方法评估其存活模式。多胞胎出生率为17.1(95%置信区间:17.7 - 16.6),且在该研究纳入的25个国家中显示出相当大的差异。多胞胎的几率随着母亲年龄增长、产次及母亲身高的增加而显著升高,但与财富指数、初产年龄及出生月份无关。在4岁末,多胞胎的累积存活概率低至0.77,而其同胞单胞胎为0.93。多胞胎的新生儿、婴儿及5岁以下儿童死亡几率分别增加了5.55倍、4.39倍和3.72倍。多胞胎往往比单胞胎营养不良,消瘦、发育迟缓及体重不足的几率分别连续提高了1.31倍、1.83倍和1.73倍。然而,多胞胎在4岁末恢复了其年龄别体重(WFA)和年龄别身高(HFA)的不足。为怀有多胞胎的孕妇提供咨询,使其在医疗机构分娩,并在新生儿期及之后提供密切的医疗随访,可提高多胞胎的存活率。