Christianson Mindy S, Mensah Virginia A, Shen Wen
Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Lutherville, MD 21093, United States.
Brown Alpert Medical School, Women & Infants Hospital, Providence, RI, United States.
Maturitas. 2015 Feb;80(2):133-9. doi: 10.1016/j.maturitas.2014.11.013. Epub 2014 Nov 27.
Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative condition of the central nervous system that preferentially afflicts women more than men. Low estrogen states such as menopause and the postpartum period favor exacerbations of multiple sclerosis in women with the disease. Existing and emerging evidence suggests a role for estrogen in the alleviation of symptoms and reversal of pathology associated with MS. While clinical evidence is sparse regarding the benefit of estrogen therapy for women at risk for MS exacerbations, scientific data demonstrates that estrogen potentiates numerous neuroprotective effects on the central nervous system (CNS). Estrogens play a wide range of roles involved in MS disease pathophysiology, including increasing antiinflammatory cytokines, decreasing demyelination, and enhancing oxidative and energy producing processes in CNS cells.
多发性硬化症（MS）是一种中枢神经系统的自身免疫性脱髓鞘和神经退行性疾病，女性比男性更容易罹患。诸如更年期和产后等雌激素水平较低的状态会促使患有该疾病的女性病情加重。现有及新出现的证据表明，雌激素在缓解与多发性硬化症相关的症状及逆转病理过程中发挥作用。虽然关于雌激素疗法对有MS病情加重风险的女性的益处的临床证据较少，但科学数据表明，雌激素对中枢神经系统（CNS）具有多种神经保护作用。雌激素在MS疾病病理生理学中发挥广泛作用，包括增加抗炎细胞因子、减少脱髓鞘以及增强CNS细胞中的氧化和能量产生过程。
