Waterman M R, Simpson E R
Recent Prog Horm Res. 1989;45:533-63; discussion 563-6. doi: 10.1016/b978-0-12-571145-6.50016-9.
In summary, regulation of steroid hydroxylase gene expression is complex and multifactorial, involving cAMP-dependent and -independent mechanisms required for maintenance of optimal steroidogenic capacity, tissue-specific mechanisms which lead to different steroidogenic pathways in different tissues, and developmental mechanisms which lead to fetal imprinting of steroid hydroxylase expression and which probably overlap with both maintenance and tissue-specific mechanisms. Future studies will involve identification of the trans-acting factors associated with each of these aspects of the multifactorial regulation and characterization of the cis-regulatory elements to which they bind. Such studies will inevitably lead to the identification of genes encoding these trans-acting factors and investigation of their regulation. In this way, it will be possible to work outward from the steroid hydroxylase genes toward the cell surface receptors in order to elucidate the series of events which lead to cAMP-dependent and -independent regulation of steroid hydroxylase gene expression.
总之，甾体羟化酶基因表达的调控是复杂且多因素的，涉及维持最佳甾体生成能力所需的cAMP依赖性和非依赖性机制、导致不同组织中不同甾体生成途径的组织特异性机制，以及导致甾体羟化酶表达的胎儿印记且可能与维持机制和组织特异性机制均重叠的发育机制。未来的研究将包括鉴定与多因素调控的这些方面相关的反式作用因子，以及对它们所结合的顺式调控元件进行表征。此类研究将不可避免地导致编码这些反式作用因子的基因的鉴定及其调控的研究。通过这种方式，有可能从甾体羟化酶基因向外研究至细胞表面受体，以阐明导致甾体羟化酶基因表达的cAMP依赖性和非依赖性调控的一系列事件。
