Andersson M, Holm G, Lefvert A K, Mellstedt H
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Scand J Immunol. 1989 Oct;30(4):489-92. doi: 10.1111/j.1365-3083.1989.tb02454.x.
The B-cell repertoire in a patient with benign monoclonal gammopathy of unknown significance was studied using Epstein-Barr virus transformation of peripheral lymphocytes. The presence of anti-idiotypic B cells producing monoclonal antibodies that reacted with idiotypic determinants on the monoclonal immunoglobulin was verified. The two monoclonal anti-idiotypic antibodies studied were of the IgM-kappa type. Such anti-idiotypic antibodies may be part of an idiotypic network regulation of the monoclonal B-cell population.
