Alsidawi Samer, Ghose Abhimanyu, Qualtieri Julianne, Radhakrishnan Neetu
Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Division of Hematology-Oncology, Department of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Case Rep Oncol Med. 2014;2014:962526. doi: 10.1155/2014/962526. Epub 2014 Dec 2.
The coexistence of multiple myeloma and chronic myeloid leukemia in a single patient is a very rare event that has been reported very infrequently in the literature. We report a case of a patient who developed chronic myeloid leukemia four years after his diagnosis with multiple myeloma. Historically, no link between the two malignancies has been identified. This synchronous existence complicates the treatment plan for these patients, and there is a lack of evidence on the best therapeutic approach. Our patient was successfully treated with a combination of bortezomib, dexamethasone, and dasatinib, which he tolerated well for eleven months until he eventually succumbed to cardiac complications and pulmonary hypertension leading to his death.
一名患者同时患有多发性骨髓瘤和慢性髓性白血病是极为罕见的情况，文献中鲜有报道。我们报告一例患者，其在被诊断为多发性骨髓瘤四年后又患上了慢性髓性白血病。从历史上看，尚未发现这两种恶性肿瘤之间存在关联。这种同步存在使这些患者的治疗方案变得复杂，并且缺乏关于最佳治疗方法的证据。我们的患者接受硼替佐米、地塞米松和达沙替尼联合治疗，效果良好，耐受了十一个月，最终因心脏并发症和肺动脉高压去世。
