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急性肝损伤大鼠消化间期移行性复合运动的变化

Changing interdigestive migrating motor complex in rats under acute liver injury.

作者信息

Liu Mei, Zheng Su-Jun, Xu Weihong, Zhang Jianying, Chen Yu, Duan Zhongping

机构信息

Artificial Liver Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China ; Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.

Artificial Liver Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.

出版信息

Biomed Res Int. 2014;2014:634281. doi: 10.1155/2014/634281. Epub 2014 Oct 28.

DOI:10.1155/2014/634281
PMID:25544942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4228720/
Abstract

Gastrointestinal motility disorder is a major clinical manifestation of acute liver injury, and interdigestive migrating motor complex (MMC) is an important indicator. We investigated the changes and characteristics of MMC in rats with acute liver injury. Acute liver injury was created by d-galactosamine, and we recorded the interdigestive MMC using a multichannel physiological recorder and compared the indexes of interdigestive MMC. Compared with normal controls, antral MMC Phase I duration was significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The duodenal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The jejunal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury compared with normal controls. Compared with the normal controls, rats with acute liver injury had a significantly prolonged interdigestive MMC cycle, related mainly to longer MMC Phases I and IV, shortened MMC Phase III, and MMC Phase II characterized by increased migrating clustered contractions, which were probably major contributors to the gastrointestinal motility disorders.

摘要

胃肠动力障碍是急性肝损伤的主要临床表现，消化间期移行性复合运动（MMC）是一项重要指标。我们研究了急性肝损伤大鼠MMC的变化及特征。用D-半乳糖胺制造急性肝损伤，使用多通道生理记录仪记录消化间期MMC，并比较消化间期MMC各项指标。与正常对照组相比，急性肝损伤大鼠胃窦MMCⅠ相持续时间显著延长，MMCⅢ相持续时间显著缩短。急性肝损伤大鼠十二指肠MMC周期以及MMCⅠ相和Ⅳ相持续时间显著延长，MMCⅢ相持续时间显著缩短。与正常对照组相比，急性肝损伤大鼠空肠MMC周期以及MMCⅠ相和Ⅳ相持续时间显著延长，MMCⅢ相持续时间显著缩短。与正常对照组相比，急性肝损伤大鼠消化间期MMC周期显著延长，主要与MMCⅠ相和Ⅳ相延长、MMCⅢ相缩短有关，且MMCⅡ相以移行性成簇收缩增加为特征，这可能是胃肠动力障碍的主要原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/4228720/4a46ece29a55/BMRI2014-634281.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/4228720/923082a343cb/BMRI2014-634281.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/4228720/4a46ece29a55/BMRI2014-634281.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/4228720/923082a343cb/BMRI2014-634281.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/4228720/4a46ece29a55/BMRI2014-634281.002.jpg

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Effects of gut microflora on hepatic damage after acute liver injury in rats.肠道微生物群对大鼠急性肝损伤后肝损伤的影响。
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