Gaudet Laura, Ferraro Zachary M, Wen Shi Wu, Walker Mark
University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5 ; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Newborn Care, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6 ; Ottawa Hospital Research Institute, Ottawa, ON, Canada K1H 8L6.
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Newborn Care, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6 ; Healthy Active Living and Obesity (HALO) Research Group, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, Canada K1H 8L1.
Biomed Res Int. 2014;2014:640291. doi: 10.1155/2014/640291. Epub 2014 Dec 7.
To determine a precise estimate for the contribution of maternal obesity to macrosomia.
The search strategy included database searches in 2011 of PubMed, Medline (In-Process & Other Non-Indexed Citations and Ovid Medline, 1950-2011), and EMBASE Classic + EMBASE. Appropriate search terms were used for each database. Reference lists of retrieved articles and review articles were cross-referenced.
All studies that examined the relationship between maternal obesity (BMI ≥30 kg/m(2)) (pregravid or at 1st prenatal visit) and fetal macrosomia (birth weight ≥4000 g, ≥4500 g, or ≥90th percentile) were considered for inclusion.
TABULATION, INTEGRATION, AND RESULTS: Data regarding the outcomes of interest and study quality were independently extracted by two reviewers. Results from the meta-analysis showed that maternal obesity is associated with fetal overgrowth, defined as birth weight ≥ 4000 g (OR 2.17, 95% CI 1.92, 2.45), birth weight ≥4500 g (OR 2.77,95% CI 2.22, 3.45), and birth weight ≥90% ile for gestational age (OR 2.42, 95% CI 2.16, 2.72).
Maternal obesity appears to play a significant role in the development of fetal overgrowth. There is a critical need for effective personal and public health initiatives designed to decrease prepregnancy weight and optimize gestational weight gain.
确定母亲肥胖对巨大儿的贡献的精确估计值。
检索策略包括在2011年对PubMed、Medline（正在处理及其他未编入索引的引文以及Ovid Medline，1950 - 2011年）和EMBASE Classic + EMBASE进行数据库检索。每个数据库使用了适当的检索词。对检索到的文章和综述文章的参考文献列表进行了交叉引用。
纳入所有研究母亲肥胖（BMI≥30 kg/m²）（孕前或首次产前检查时）与胎儿巨大儿（出生体重≥4000 g、≥4500 g或≥第90百分位数）之间关系的研究。
制表、整合与结果：两名评审员独立提取有关感兴趣的结果和研究质量的数据。荟萃分析结果表明，母亲肥胖与胎儿过度生长相关，定义为出生体重≥4000 g（比值比2.17，95%可信区间1.92，2.45）、出生体重≥4500 g（比值比2.77，95%可信区间2.22，3.45）以及出生体重≥胎龄的第90百分位数（比值比2.42，95%可信区间2.16，2.72）。
母亲肥胖似乎在胎儿过度生长的发生中起重要作用。迫切需要有效的个人和公共卫生举措，以降低孕前体重并优化孕期体重增加。
