Yee J K
Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla 92093.
Science. 1989 Nov 3;246(4930):658-61. doi: 10.1126/science.2554495.
An 88-base pair fragment in the core promoter of the human hepatitis B virus (HBV) contains a functional promoter and a strong liver-specific enhancer. This enhancer functions in human hepatoma cells, where it is much more active than the previously described HBV enhancer in stimulating expression of the linked bacterial chloramphenicol acetyltransferase gene expressed from heterologous promoters. Studies of the role of this enhancer-promoter in HBV may help to clarify mechanisms of gene expression in cells infected with HBV and the role of the virus in the pathogenesis of hepatitis and hepatocellular carcinoma.
人类乙型肝炎病毒（HBV）核心启动子中的一个88个碱基对的片段包含一个功能性启动子和一个强大的肝脏特异性增强子。该增强子在人肝癌细胞中发挥作用，在刺激从异源启动子表达的连接细菌氯霉素乙酰转移酶基因的表达方面，它比先前描述的HBV增强子更具活性。对该增强子-启动子在HBV中的作用进行研究，可能有助于阐明HBV感染细胞中基因表达的机制以及该病毒在肝炎和肝细胞癌发病机制中的作用。
