Steffey Michele A, Daniel Leticia, Taylor Sandra L, Chen Rachel X, Zwingenberger Allison L
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95615.
Vet Radiol Ultrasound. 2015 May-Jun;56(3):278-85. doi: 10.1111/vru.12235. Epub 2014 Dec 28.
Objectives of this prospective study were to describe effects of varying technical components that may contribute to an optimal protocol for computed tomographic pneumocolonography (CTP) in dogs, and to develop a standardized methodology for CTP as a future potential diagnostic tool in canine clinical patients with large bowel disease. Eight purpose-bred intact male hound cross-research dogs were enrolled and randomized to groups based on variables of pressure/body position (n = 4) and insufflation time (n = 4). For each segment of large bowel (rectum, colorectal junction, descending colon, transverse colon, ascending colon), the adequacy of bowel preparation, % of bowel lumen filled with fecal material, and bowel tortuosity or folding were assessed. Measurements of bowel wall thickness (cm), cross-sectional bowel lumen diameter (cm), and cross-sectional bowel luminal area (cm(2) ) were obtained at standardized locations within the large bowel. False discovery rates (FDR) were calculated to adjust for multiple testing. Values of FDR < 0.05 were considered significant. Differences in mean cross-sectional area and diameter and bowel wall thickness under increasing pressure were not significant after adjusting for multiple testing; some had raw p values <0.05. Ascending colon diameter and ascending colon area significantly increased with insufflation time (FDR < 0.05). No other response variables showed a significant change with insufflation time. The optimal insufflation pressure for maintaining pneumocolon in this study was determined to be 20 mmHg. CTP is a feasible technique to provide consistent distension for imaging of the large bowel and further study on application of CTP in clinical patients is warranted.
这项前瞻性研究的目的是描述各种技术因素对犬计算机断层扫描气钡双重造影（CTP）最佳方案的影响，并开发一种标准化的CTP方法，作为未来犬大肠疾病临床患者潜在的诊断工具。八只专门培育的未阉割雄性杂交猎犬被纳入研究，并根据压力/体位变量（n = 4）和充气时间变量（n = 4）随机分组。对大肠的每个节段（直肠、结直肠交界处、降结肠、横结肠、升结肠）评估肠道准备的充分程度、肠腔内粪便填充的百分比以及肠管的曲折或折叠情况。在大肠内的标准化位置测量肠壁厚度（cm）、肠腔横径（cm）和肠腔横截面积（cm²）。计算错误发现率（FDR）以校正多重检验。FDR值<0.05被认为具有统计学意义。在进行多重检验校正后，压力增加时平均横截面积、直径和肠壁厚度的差异无统计学意义；一些原始p值<0.05。随着充气时间的增加，升结肠直径和升结肠面积显著增加（FDR<0.05）。没有其他反应变量随充气时间显示出显著变化。本研究确定维持气钡双重造影的最佳充气压力为20 mmHg。CTP是一种可行的技术，可为大肠成像提供一致的扩张，有必要进一步研究CTP在临床患者中的应用。
