Decreased phosphofructokinase activity during the development of triorthocresyl-phosphate-induced delayed neuropathy.

作者信息

Hernandez A F, Pla A, Villanueva E

机构信息

Department of Legal Medicine and Toxicology Service, Faculty of Medicine, University Hospital, University of Granada, Spain.

出版信息

Toxicol Lett. 1989 Oct;49(1):35-40. doi: 10.1016/0378-4274(89)90098-2.

The effect of triorthocresyl phosphate on selected glycolytic enzymes (hexokinase, phosphofructokinase, glyceraldehyde 3-phosphate dehydrogenase, lactate dehydrogenase) was investigated during the development of organophosphate-induced delayed neuropathy. Only phosphofructokinase activity was decreased 15 days after treatment. The effect was dose-dependent and was observed in sciatic nerve while the brain enzyme activity was not affected.