Shields Jerry A, Eagle Ralph C, Ferguson Kyle, Shields Carol L
*Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania; and †Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
Retina. 2015 May;35(5):957-65. doi: 10.1097/IAE.0000000000000445.
In 1970, Dr. Lorenz Zimmerman delivered the Norman McAlister Gregg Lecture entitled "The remarkable polymorphism of tumors of the ciliary epithelium." Therein, he proposed a classification of these tumors that included congenital lesions (mainly medulloepithelioma) and acquired lesions (mainly adenoma and adenocarcinoma). The classification was based on histopathologic observations without detailed clinical information.
Review of the published literature and personal experience with tumors of the nonpigmented ciliary body epithelium.
Since 1970, further observations through clinical examination and advanced testing with ultrasound biomicroscopy, anterior segment optical coherence tomography, and magnetic resonance imaging have expanded our knowledge regarding tumors of the nonpigmented ciliary body epithelium. Regarding medulloepithelioma, we have learned of the common associated features of neovascular glaucoma, retrolenticular neoplastic or vascular cyclitic membrane, intralesional cysts, response to radiotherapy, and association with Dicer-1 mutation. Regarding adenoma/adenocarcinoma, improved management with surgical resection (sparing globe) can be achieved. Fuchs adenoma, also termed coronal adenoma, is commonly found histopathologically, despite its rare clinical visualization, and should be added to the Zimmerman classification.
Since Zimmerman's report on histopathologic features of tumors of the nonpigmented ciliary body epithelium, there have been numerous publications and further observations on the clinical features and management of these intriguing neoplasms.
1970年，洛伦兹·齐默尔曼博士发表了题为“睫状体上皮肿瘤的显著多态性”的诺曼·麦卡利斯特·格雷格讲座。在讲座中，他提出了这些肿瘤的一种分类方法，包括先天性病变（主要是髓上皮瘤）和后天性病变（主要是腺瘤和腺癌）。该分类基于组织病理学观察，缺乏详细的临床信息。
回顾已发表的文献以及本人对无色素睫状体上皮肿瘤的经验。
自1970年以来，通过临床检查以及超声生物显微镜、眼前段光学相干断层扫描和磁共振成像等先进检测手段进行的进一步观察，扩展了我们对无色素睫状体上皮肿瘤的认识。关于髓上皮瘤，我们了解到其与新生血管性青光眼、晶状体后肿瘤性或血管性睫状体膜、瘤内囊肿、对放疗的反应以及与Dicer-1突变相关的常见特征。关于腺瘤/腺癌，可以通过手术切除（保留眼球）实现更好的治疗。富克斯腺瘤，也称为冠状腺瘤，尽管临床罕见，但在组织病理学上常见，应添加到齐默尔曼分类中。
自从齐默尔曼报告无色素睫状体上皮肿瘤的组织病理学特征以来，已有大量关于这些有趣肿瘤的临床特征和治疗的出版物及进一步观察。
