Martin Erika G, MacDonald Roderick H, Smith Lou C, Gordon Daniel E, Tesoriero James M, Laufer Franklin N, Leung Shu-Yin J, Rowe Kirsten A, OʼConnell Daniel A
*Nelson A. Rockefeller Institute of Government, State University of New York, and Department of Public Administration and Policy, Rockefeller College of Public Affairs and Policy, University at Albany, State University of New York, Albany, NY; †AIDS Institute, New York State Department of Health, New York, NY; and ‡Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Albany, NY.
J Acquir Immune Defic Syndr. 2015 Jan 1;68 Suppl 1:S59-67. doi: 10.1097/QAI.0000000000000395.
A 2010 New York law requires that patients aged 13-64 years be offered HIV testing in routine medical care settings. Past studies report the clinical outcomes, cost-effectiveness, and budget impact of expanded HIV testing nationally and within clinics but have not examined how state policies affect resource needs and epidemic outcomes.
A system dynamics model of HIV testing and care was developed, where disease progression and transmission differ by awareness of HIV status, engagement in care, and disease stage. Data sources include HIV surveillance, Medicaid claims, and literature. The model projected how alternate implementation scenarios would change new infections, diagnoses, linkage to care, and living HIV cases over 10 years.
Without the law, the model projects declining new infections, newly diagnosed cases, individuals newly linked to care, and fraction of undiagnosed cases (reductions of 62.8%, 59.7%, 54.1%, and 57.8%) and a slight increase in living diagnosed cases and individuals in care (2.2% and 6.1%). The law will further reduce new infections, diagnosed AIDS cases, and the fraction undiagnosed and initially increase and then decrease newly diagnosed cases. Outcomes were consistent across scenarios with different testing offer frequencies and implementation times but differed according to the level of implementation.
A mandatory offer of HIV testing may increase diagnoses and avert infections but will not eliminate the epidemic. Despite declines in new infections, previously diagnosed cases will continue to need access to antiretroviral therapy, highlighting the importance of continued funding for HIV care.
2010年纽约州一项法律要求,在常规医疗环境中为13至64岁的患者提供艾滋病毒检测。以往的研究报告了全国范围内以及各诊所扩大艾滋病毒检测的临床结果、成本效益和预算影响,但尚未研究州政策如何影响资源需求和疫情结果。
开发了一个艾滋病毒检测与治疗的系统动力学模型,其中疾病进展和传播因艾滋病毒感染状况知晓情况、接受治疗情况以及疾病阶段而异。数据来源包括艾滋病毒监测、医疗补助索赔和文献。该模型预测了不同实施方案在10年内将如何改变新感染病例、诊断病例、接受治疗的关联情况以及现存艾滋病毒病例数。
若无此项法律,该模型预测新感染病例、新诊断病例、新接受治疗的个体以及未诊断病例比例将会下降(分别下降62.8%、59.7%、54.1%和57.8%),而现存诊断病例和接受治疗的个体将略有增加(分别增加2.2%和6.1%)。这项法律将进一步减少新感染病例、诊断出的艾滋病病例以及未诊断病例比例,并使新诊断病例数先增加后减少。不同检测提供频率和实施时间的方案结果一致,但因实施程度而异。
强制提供艾滋病毒检测可能会增加诊断并避免感染,但无法消除疫情。尽管新感染病例有所减少,但先前诊断出的病例仍将继续需要获得抗逆转录病毒治疗,这凸显了持续为艾滋病毒治疗提供资金的重要性。