Dieckmann K P, Loy V, Huland H
Urologische Klinik, Klinikum Steglitz der Freien Universität Berlin.
Urologe A. 1989 Sep;28(5):271-80.
The term "carcinoma in situ (CIS) of the testis" is used to mean the presence of atypical neoplastic spermatogonia exhibiting distinct morphological and immunohistological characteristics that differentiate them from normal germ cells. The lesion is considered to be the uniform precursor cell of all germ cell tumors, and it can usually be detected many years before manifestation of the tumor by surgical biopsy and subsequent immunohistological staining for placental alkaline phosphatase (PIAP). This paper gives a review of the theoretical and clinical features of CIS. The description is based on data in the literature and on the authors' experience with two recently detected cases of CIS in the contralateral testis of patients with germ cell tumors. In view of the observation of intraepithelial spread inside the seminiferous tubules, the term "testicular intraepithelial neoplasia" (TIN) is suggested instead of carcinoma in situ.
术语“睾丸原位癌（CIS）”用于指存在非典型肿瘤性精原细胞，这些细胞具有独特的形态学和免疫组织学特征，使其与正常生殖细胞区分开来。该病变被认为是所有生殖细胞肿瘤的统一前体细胞，通常可在肿瘤出现前多年通过手术活检及随后的胎盘碱性磷酸酶（PIAP）免疫组织化学染色检测到。本文综述了原位癌的理论和临床特征。描述基于文献数据以及作者对近期在生殖细胞肿瘤患者对侧睾丸中检测到的两例原位癌病例的经验。鉴于观察到生精小管内的上皮内扩散，建议使用术语“睾丸上皮内瘤变”（TIN）而非原位癌。
