Kleinschmidt K, Kemper J, Holstein A F
Department of Urology, Städtisches Krankenhaus am Urban, Berlin.
Eur Urol. 1989;16(1):74-7.
Carcinoma in situ (CIS) of the testis is considered a precursor of germ cell tumor. Diagnosis is made by biopsy, a procedure which is justifiable for patients with increased tumor risk. This group includes patients with testicular tumors who may develop contralateral second malignancies. After obtaining contralateral biopsies from 21 such patients we found one CIS. Treatment consisted of local irradiation (20 Gy) of the remaining testis. No clinical side effects were observed. In a control biopsy 6 months later, no evidence of CIS was found. Leydig cells were morphologically normal. Nine months after therapy, plasma testosterone levels were still normal, LH and FSH levels were increased. Long-term observations are needed to assess the value of radiotherapy as compared to orchiectomy.
睾丸原位癌（CIS）被认为是生殖细胞肿瘤的前驱病变。诊断通过活检进行，对于肿瘤风险增加的患者，该操作是合理的。这一群体包括可能发生对侧第二原发恶性肿瘤的睾丸肿瘤患者。在从21例此类患者中获取对侧活检样本后，我们发现了1例原位癌。治疗包括对剩余睾丸进行局部照射（20 Gy）。未观察到临床副作用。6个月后的对照活检中，未发现原位癌证据。间质细胞形态正常。治疗9个月后，血浆睾酮水平仍正常，促黄体生成素（LH）和促卵泡生成素（FSH）水平升高。需要进行长期观察以评估放疗与睾丸切除术相比的价值。
