Hernandez Brenda Y, Goodman Marc T, Lynch Charles F, Cozen Wendy, Unger Elizabeth R, Steinau Martin, Thompson Trevor, Saber Maria Sibug, Altekruse Sean F, Lyu Christopher, Saraiya Mona
University of Hawaii Cancer Center, University of Hawaii, Honolulu, Hawaii, United States of America.
Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
PLoS One. 2014 Dec 29;9(12):e115931. doi: 10.1371/journal.pone.0115931. eCollection 2014.
Human papillomavirus (HPV) is a major risk factor for specific cancers of the head and neck, particularly malignancies of the tonsil and base of the tongue. However, the role of HPV in the development of laryngeal cancer has not been definitively established. We conducted a population-based, cancer registry study to evaluate and characterize the genotype-specific prevalence of HPV in invasive laryngeal cancer cases diagnosed in the U.S.
The presence of genotype-specific HPV DNA was evaluated using the Linear Array HPV Genotyping Test and the INNO-LiPA HPV Genotyping Assay in formalin-fixed paraffin embedded tissue from 148 invasive laryngeal cancer cases diagnosed in 1993-2004 within the catchment area of three U.S. SEER cancer registries.
HPV DNA was detected in 31 of 148 (21%) invasive laryngeal cancers. Thirteen different genotypes were detected. Overall, HPV 16 and HPV 33 were the most commonly detected types. HPV was detected in 33% (9/27) of women compared with 18% (22/121) of men (p = 0.08). After adjustment for age and year of diagnosis, female patients were more likely to have HPV-positive laryngeal tumors compared to males (adjusted OR 2.84, 95% CI 1.07-7.51). Viral genotype differences were also observed between the sexes. While HPV 16 and 18 constituted half of HPV-positive cases occurring in men, among women, only 1 was HPV 16 positive and none were positive for HPV 18. Overall 5-year survival did not vary by HPV status.
HPV may be involved in the development of a subset of laryngeal cancers and its role may be more predominant in women compared to men.
人乳头瘤病毒（HPV）是头颈部特定癌症的主要风险因素，尤其是扁桃体和舌根恶性肿瘤。然而，HPV在喉癌发生中的作用尚未明确确立。我们开展了一项基于人群的癌症登记研究，以评估和描述美国诊断的浸润性喉癌病例中HPV基因型特异性的流行情况。
使用线性阵列HPV基因分型检测和INNO-LiPA HPV基因分型检测法，对1993年至2004年在美国三个监测、流行病学和最终结果（SEER）癌症登记处辖区内诊断的148例浸润性喉癌病例的福尔马林固定石蜡包埋组织中的基因型特异性HPV DNA进行评估。
在148例浸润性喉癌中有31例（21%）检测到HPV DNA。检测到13种不同的基因型。总体而言，HPV 16和HPV 33是最常检测到的类型。女性中有33%（9/27）检测到HPV，而男性为18%（
