p16（INK4A）在喉浸润癌中的表达
p16(INK4A) expression in invasive laryngeal cancer.
作者信息
Hernandez Brenda Y, Rahman Mobeen, Lynch Charles F, Cozen Wendy, Unger Elizabeth R, Steinau Martin, Thompson Trevor, Saber Maria Sibug, Altekruse Sean F, Goodman Marc T, Powers Amy, Lyu Christopher, Saraiya Mona
机构信息
University of Hawaii Cancer Center, 701 Ilalo Street #239, Honolulu, Hawaii, USA 96813.
University of Hawaii John A. Burns School of Medicine, 651 Ilalo Street #411E, Honolulu, Hawaii, USA 96813.
出版信息
Papillomavirus Res. 2016 Dec;2:52-55. doi: 10.1016/j.pvr.2016.03.001. Epub 2016 Mar 9.
We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA. Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16 expression was observed in 2 of 16 (12.5%) cases previously determined to be HPV DNA positive. The two cases dually positive for p16 and HPV DNA were non-keratinizing SCC and papillary SCC tumors that were positive for genotypes 18 and 35/89, respectively. Positivity for p16 and/or HPV DNA was not associated with 5-year survival (log-rank p value= 0.55). Our findings support a limited role of HPV in laryngeal carcinogenesis. p16 is not a reliable surrogate for HPV status in laryngeal cancers and is not a predictor of laryngeal cancer survival.
我们在美国诊断的基于人群样本的喉癌病例肿瘤中检测了p16表达。样本先前已进行HPV DNA基因分型。总体而言，101例病例中有8例（7.9%）的喉组织中观察到p16表达。在先前确定为HPV DNA阳性的16例病例中有2例（12.5%）观察到p16表达。p16和HPV DNA双阳性的两例病例分别为非角化性鳞状细胞癌和乳头状鳞状细胞癌肿瘤，分别对18型和35/89型基因型呈阳性。p16和/或HPV DNA阳性与5年生存率无关（对数秩p值 = 0.55）。我们的研究结果支持HPV在喉癌发生中作用有限。p16不是喉癌中HPV状态的可靠替代指标，也不是喉癌生存的预测指标。
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