Murunikkara Vachana, Rasool Mahaboob K
Immunopathology Laboratory, School of Bio Sciences and Technology, VIT University, Vellore, India.
Int J Rheum Dis. 2017 Mar;20(3):298-308. doi: 10.1111/1756-185X.12535. Epub 2014 Dec 26.
Rheumatoid arthritis is a chronic inflammatory autoimmune disorder with multi-factorial factors influencing disease alleviation in synovial joints. The aim of this study was to investigate the anti-arthritic efficacy of trikatu, a herbal compound, on biochemical and immunological complications in adjuvant-induced arthritic rats.
Arthritis was induced in rats by a single intradermal injection of complete Freund's adjuvant (0.1 mL) into the foot pad of the right hind paw. Trikatu (1000 mg/kg body weight, oral) and indomethacin (3 mg/kg body weight, intrap intraperitoneal) were administered for 8 days from days 11 to 18 after adjuvant injection.
Our present study results evidenced a significant alteration in the activities/levels of lysosomal enzymes, protein bound carbohydrates, bone collagen, urinary constituents like hydroxyproline and total glycosaminoglycans, lipid peroxidation, antioxidant status, lipid profiles, rheumatoid factor and inflammatory mediators in adjuvant-induced arthritic rats. Trikatu treatment (1000 mg/kg/body weight) reverted back all the above biochemical and immunological parameters to near normal levels in arthritic rats as evidenced by the radiological and histopathological assessements .
These results suggest that trikatu could be a promising alternative drug for the control and management of rheumatoid arthritis.
类风湿性关节炎是一种慢性炎症性自身免疫性疾病，多种因素影响滑膜关节疾病的缓解。本研究的目的是研究草药化合物三卡图对佐剂诱导性关节炎大鼠生化和免疫并发症的抗关节炎疗效。
通过将完全弗氏佐剂（0.1 mL）单次皮内注射到右后爪的足垫中诱导大鼠患关节炎。从佐剂注射后的第11天至第18天，给予三卡图（1000 mg/kg体重，口服）和吲哚美辛（3 mg/kg体重，腹腔内注射），持续8天。
我们目前的研究结果表明，佐剂诱导性关节炎大鼠的溶酶体酶、蛋白结合碳水化合物、骨胶原、尿成分如羟脯氨酸和总糖胺聚糖、脂质过氧化作用、抗氧化状态、血脂谱、类风湿因子和炎症介质的活性/水平发生了显著变化。三卡图治疗（1000 mg/kg体重）使上述所有生化和免疫参数在关节炎大鼠中恢复到接近正常水平，这一点通过放射学和组织病理学评估得到了证实。
这些结果表明，三卡图可能是控制和管理类风湿性关节炎的一种有前景的替代药物。
