Cai N S, Xiao W B, Zhou T C
Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):101-3.
The GABA receptor agonists GABA (400 micrograms icv) and muscimol (1 microgram icv) induced hypotension in urethane-anesthetized rats, while the GABA receptor antagonist bicuculline (2 micrograms icv) elicited hypertension. An endogenous GABA receptor binding inhibitor (1 mg), prepared from bovine cerebellum, showed bicuculline-like hypertensive action in a dose-dependent manner. It was antagonized by icv muscimol, but not by the alpha 2-adrenoceptor agonist clonidine. These in vivo results agree quite well with our previous in vitro receptor binding assay experiments.
γ-氨基丁酸（GABA）受体激动剂GABA（脑室内注射400微克）和蝇蕈醇（脑室内注射1微克）可使氨基甲酸乙酯麻醉的大鼠血压降低，而GABA受体拮抗剂荷包牡丹碱（脑室内注射2微克）则引起血压升高。从小牛小脑制备的一种内源性GABA受体结合抑制剂（1毫克）呈剂量依赖性地表现出类似荷包牡丹碱的升压作用。它可被脑室内注射的蝇蕈醇拮抗，但不能被α2-肾上腺素能受体激动剂可乐定拮抗。这些体内实验结果与我们之前的体外受体结合试验实验结果非常吻合。
