Li Zheng, Wang Wei, Zhou Minwen, Huang Wenbin, Chen Shida, Li Xingyi, Gao Xinbo, Wang Jiawei, Du Shaolin, Zhang Xiulan
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
Department of Ophthalmology, The 1st People's Hospital of Chenzhou City, Chenzhou, China.
Acta Ophthalmol. 2015 Aug;93(5):e349-e355. doi: 10.1111/aos.12616. Epub 2014 Dec 28.
To compare the choroidal thickness (CT) in eyes with moderate and severe primary angle-closure glaucoma (PACG) with the eyes of healthy controls.
Fifty-nine patients (59 eyes) with PACG and 56 age-matched normal subjects underwent macular CT scanning using enhanced depth imaging-optical coherence tomography. The subjects with PACG were further classified as having moderate [-12 dB ≤ visual field mean deviation (VF-MD) ≤ -6 dB] or severe (VF-MD < -12 dB) glaucoma. The average CT of the PACG eyes at each location was compared to that of normal eyes.
The CT was significantly increased in moderate and severe PACG eyes compared with the normal eyes at all nine macular locations, with the exception of 1 and 3 mm superior to the fovea. The mean CT under the fovea was 292.0 ± 48.2 μm in the moderate PACG eyes, 277.1 ± 58.3 μm in the severe PACG eyes and 249.9 ± 72.1 μm in the normal eyes, respectively. There were no significant differences between the macular CTs in the eyes with moderate PACG and those in severe PACG eyes (all p > 0.05). Factors associated with a thinner choroid were ageing (p < 0.001), female (p = 0.036) and increasing axial length (p = 0.021). Neither the VF-MD nor pattern standard deviation was found to be associated with CT.
The CT is greater in patients with PACG, but it does not differ between moderate and severe PACG, suggesting a lack of relationship between CT and the progression of glaucoma based on EDI-OCT measurements.
比较中度和重度原发性闭角型青光眼（PACG）患者与健康对照者的脉络膜厚度（CT）。
59例（59只眼）PACG患者和56例年龄匹配的正常受试者接受了增强深度成像光学相干断层扫描以进行黄斑CT扫描。PACG患者进一步分为中度[-12 dB≤视野平均缺损（VF-MD）≤-6 dB]或重度（VF-MD＜-12 dB）青光眼。比较PACG组各部位眼睛的平均CT与正常眼睛的平均CT。
除黄斑中心凹上方1和3 mm处外，在所有9个黄斑部位，中度和重度PACG组眼睛的CT均显著高于正常眼睛。中度PACG组眼睛黄斑中心凹下的平均CT为292.0±48.2μm，重度PACG组眼睛为277.1±58.3μm，正常眼睛为249.9±72.1μm。中度PACG组眼睛与重度PACG组眼睛的黄斑CT之间无显著差异（所有p＞0.05）。与脉络膜较薄相关的因素为年龄增长（p＜0.001）、女性（p = 0.036）和眼轴长度增加（p = 0.021）。未发现VF-MD和模式标准差与CT相关。
PACG患者的CT更大，但中度和重度PACG之间无差异，这表明基于增强深度成像光学相干断层扫描测量，CT与青光眼进展之间缺乏相关性。
